Rosemary Extracts Upregulate Nrf2, Sestrin2, and MRP2 Protein Level in Human Hepatoma HepG2 Cells
Joint Authors
Yan, Miao
Ma, Yan-Xia
Tong, Xiao-pei
Quan, Dan-ni
Zhang, Ling
Fan, Xin-rong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
In the past few decades, the incidence of liver cancer has been rapidly rising across the world.
Rosemary is known to possess antioxidant activity and is used as natural antioxidant food preservative.
It is proposed to have anticancer activity in treating different tumor models.
In this study, we try to explore the impact of rosemary extracts on upregulating the level of Nrf2 and Nrf2-regulatory proteins, Sestrin2 and MRP2 in HepG2 cells, and to speculate its potential mechanism.
The anticancer activity of rosemary extract, including its polyphenolic diterpenes carnosic acid and carnosol, was evaluated to understand the potential effect on HepG2 cells.
Rosemary extract, carnosic acid, and carnosol induced the expression of Sestrin2 and MRP2 associate with enhancement of Nrf2 protein level in HepG2 cells, in which carnosic acid showed most obvious effect.
Although the activation pathway of Nrf2/ARE was not exactly assessed, it can be assumed that the enhancement of expression of Sestrin2 and MRP2 may result from upregulation of Nrf2.
American Psychological Association (APA)
Tong, Xiao-pei& Ma, Yan-Xia& Quan, Dan-ni& Zhang, Ling& Yan, Miao& Fan, Xin-rong. 2017. Rosemary Extracts Upregulate Nrf2, Sestrin2, and MRP2 Protein Level in Human Hepatoma HepG2 Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1154525
Modern Language Association (MLA)
Tong, Xiao-pei…[et al.]. Rosemary Extracts Upregulate Nrf2, Sestrin2, and MRP2 Protein Level in Human Hepatoma HepG2 Cells. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1154525
American Medical Association (AMA)
Tong, Xiao-pei& Ma, Yan-Xia& Quan, Dan-ni& Zhang, Ling& Yan, Miao& Fan, Xin-rong. Rosemary Extracts Upregulate Nrf2, Sestrin2, and MRP2 Protein Level in Human Hepatoma HepG2 Cells. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1154525
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154525