Ficus hispida Bark Extract Prevents Nociception, Inflammation, and CNS Stimulation in Experimental Animal Model
Joint Authors
Hossain, Hemayet
Siraj, Md. Afjalus
Howlader, Md. Sariful Islam
Dey, Shubhra Kanti
Hira, Arpona
Ahmed, Arif
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-12
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Background.
Ficus hispida is traditionally used in the ailment of pain, inflammation, and neurological disorders.
The present study set out to evaluate the in vivo antinociceptive, anti-inflammatory, and sedative activity of the ethanol extract of Ficus hispida bark (EFHB).
Methods.
The antinociceptive activity of EFHB was evaluated by using acetic acid induced writhing, formalin, hot plate, and tail immersion methods in Swiss albino mice.
Its anti-inflammatory activity was assessed by using carrageenan and histamine induced rat paw oedema test in Wister rats.
The central stimulating activity was studied by using pentobarbital induced hypnosis, hole cross, and open field tests in Swiss albino mice.
Results.
EFHB demonstrated antinociceptive activity both centrally and peripherally.
It showed 62.24% of writhing inhibition.
It significantly inhibited licking responses in early (59.29%) and late phase (71.61%).
It increased the reaction time to the thermal stimulus in both hot plate and tail immersion.
It inhibited the inflammation to the extent of 59.49%.
A substantial increase in duration of sleep up to 60.80 min and decrease of locomotion up to 21.70 at 400 mg/kg were also observed.
Conclusion.
We found significant dose dependent antinociceptive, anti-inflammatory, and sedative properties of EFHB in experimental animal models.
American Psychological Association (APA)
Howlader, Md. Sariful Islam& Siraj, Md. Afjalus& Dey, Shubhra Kanti& Hira, Arpona& Ahmed, Arif& Hossain, Hemayet. 2017. Ficus hispida Bark Extract Prevents Nociception, Inflammation, and CNS Stimulation in Experimental Animal Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1154536
Modern Language Association (MLA)
Howlader, Md. Sariful Islam…[et al.]. Ficus hispida Bark Extract Prevents Nociception, Inflammation, and CNS Stimulation in Experimental Animal Model. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1154536
American Medical Association (AMA)
Howlader, Md. Sariful Islam& Siraj, Md. Afjalus& Dey, Shubhra Kanti& Hira, Arpona& Ahmed, Arif& Hossain, Hemayet. Ficus hispida Bark Extract Prevents Nociception, Inflammation, and CNS Stimulation in Experimental Animal Model. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1154536
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154536