Home-Based Transcutaneous Neuromodulation Improved Constipation via Modulating Gastrointestinal Hormones and Bile Acids
Joint Authors
Zhang, Nina
Chen, Jiande DZ
Ge, Zhenyang
Duan, Zhijun
Yang, Hang
Zhang, Shengai
Zhang, Shuang
Wang, Lixia
Yang, Dong
Sun, Xiaoyu
Zhang, Zhifeng
Su, Liping
Zhu, Hong
Zhou, Dongdong
Liu, Bojia
Shi, Honggang
Yu, Jun
Yang, Hui
Chang, Qingyong
Wu, Dongsheng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-29
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
This study aims to investigate the role of transcutaneous neuromodulation (TN) on the regulation of gastrointestinal hormones and bile acids in patients with functional constipation (FC).
Twenty FC patients were treated with TN for four weeks.
The effects of TN on symptoms were evaluated by questionnaires.
Plasma levels of serotonin (5-HT), motilin, somatostatin, and vasoactive intestinal peptide (VIP) were measured by ELISA and 12 individual bile acids assayed by liquid chromatography tandem mass spectrometry.
Results were as follows.
(1) TN treatment increased the frequency of spontaneous bowel movement, improved the Bristol Stool Score, and reduced Patient Assessment of Constipation Symptom score and Patient Assessment of Constipation Quality of Life score.
(2) FC patients showed decreased plasma levels of 5-HT, motilin, and VIP and an increased plasma level of somatostatin (P<0.05).
Four-week TN treatment increased plasma levels of 5-HT and motilin and decreased the plasma level of somatostatin in the FC patients (P<0.05).
(3) Taurocholic deoxycholate, taurocholic acid, and taurocholic lithocholic acid were increased in the FC patients (P<0.005) but reduced by TN treatment (P<0.05).
This study has suggested that the therapy may improve the symptoms of FC by alleviating the disorders of gastrointestinal hormones and bile acids.
American Psychological Association (APA)
Ge, Zhenyang& Duan, Zhijun& Yang, Hang& Zhang, Shengai& Zhang, Shuang& Wang, Lixia…[et al.]. 2018. Home-Based Transcutaneous Neuromodulation Improved Constipation via Modulating Gastrointestinal Hormones and Bile Acids. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1154539
Modern Language Association (MLA)
Ge, Zhenyang…[et al.]. Home-Based Transcutaneous Neuromodulation Improved Constipation via Modulating Gastrointestinal Hormones and Bile Acids. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1154539
American Medical Association (AMA)
Ge, Zhenyang& Duan, Zhijun& Yang, Hang& Zhang, Shengai& Zhang, Shuang& Wang, Lixia…[et al.]. Home-Based Transcutaneous Neuromodulation Improved Constipation via Modulating Gastrointestinal Hormones and Bile Acids. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1154539
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154539