Metabolic Profiling Analysis of the Alleviation Effect of the Fractions of Niuhuang Jiedu Tablet on Realgar Induced Toxicity in Rats
Joint Authors
Xu, Wenfeng
Xu, Shuo
Jin, Pengfei
Pei, Yuehu
Wang, Haifeng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-23
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Niuhuang Jiedu Tablet (NJT) is a classical formula in treating acute tonsillitis, pharyngitis, and so on.
In the formula, significant level of Realgar as a potentially toxic element is contained.
Our previous experiments revealed that it was less toxic for combined Realgar in NJT.
However, the active fraction of this prescription with toxicity alleviation effect on Realgar was still obscure.
NJT was divided into five different polar fractions (NJT-PET, NJT-25, NJT-50, NJT-75, and NJT-95), and we explored the toxicity alleviation effect on Realgar.
Based on 1H NMR spectra of urine and serum from rats, PCA and PLS-DA were performed to identify different metabolic profiles.
Liver and kidney histopathology examinations and serum clinical chemistry analysis were also performed.
With pattern recognition analysis of metabolites in urine and serum, Realgar group showed a clear separation from control group, while the metabolic profiles of NJT-PET, NJT-25, NJT-50, and NJT-95 groups were similar to Realgar group, and the metabolic profiles of NJT and NJT-75 groups were very close to control group.
Statistics results were confirmed by the histopathological examination and biochemical assay.
The present work indicated that 75% EtOH fraction of NJT was the most valid fraction with the toxicity alleviation effect on Realgar.
American Psychological Association (APA)
Xu, Wenfeng& Pei, Yuehu& Xu, Shuo& Wang, Haifeng& Jin, Pengfei. 2018. Metabolic Profiling Analysis of the Alleviation Effect of the Fractions of Niuhuang Jiedu Tablet on Realgar Induced Toxicity in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1154542
Modern Language Association (MLA)
Xu, Wenfeng…[et al.]. Metabolic Profiling Analysis of the Alleviation Effect of the Fractions of Niuhuang Jiedu Tablet on Realgar Induced Toxicity in Rats. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1154542
American Medical Association (AMA)
Xu, Wenfeng& Pei, Yuehu& Xu, Shuo& Wang, Haifeng& Jin, Pengfei. Metabolic Profiling Analysis of the Alleviation Effect of the Fractions of Niuhuang Jiedu Tablet on Realgar Induced Toxicity in Rats. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1154542
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154542