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The Protective Effect of Lavender Essential Oil and Its Main Component Linalool against the Cognitive Deficits Induced by D-Galactose and Aluminum Trichloride in Mice
Joint Authors
Liu, Xin-Min
Xu, Pan
Wang, Kezhu
Lu, Cong
Dong, Liming
Gao, Li
Yan, Ming
Aibai, Silafu
Yang, Yanyan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Lavender essential oil (LO) is a traditional medicine used for the treatment of Alzheimer’s disease (AD).
It was extracted from Lavandula angustifolia Mill.
This study was designed to investigate the effects of lavender essential oil (LO) and its active component, linalool (LI), against cognitive impairment induced by D-galactose (D-gal) and AlCl3 in mice and to explore the related mechanisms.
Our results revealed that LO (100 mg/kg) or LI (100 mg/kg) significantly protected the cognitive impairments as assessed by the Morris water maze test and step-though test.
The mechanisms study demonstrated that LO and LI significantly protected the decreased activity of superoxide dismutase (SOD), glutathione peroxidase (GPX), and protected the increased activity of acetylcholinesterase (AChE) and content of malondialdehyde (MDA).
Besides, they protected the suppressed nuclear factor-erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) expression significantly.
Moreover, the decreased expression of synapse plasticity-related proteins, calcium-calmodulin-dependent protein kinase II (CaMKII), p-CaMKII, brain-derived neurotrophic factor (BDNF), and TrkB in the hippocampus were increased with drug treatment.
In conclusion, LO and its active component LI have protected the oxidative stress, activity of cholinergic function and expression of proteins of Nrf2/HO-1 pathway, and synaptic plasticity.
It suggest that LO, especially LI, could be a potential agent for improving cognitive impairment in AD.
American Psychological Association (APA)
Xu, Pan& Wang, Kezhu& Lu, Cong& Dong, Liming& Gao, Li& Yan, Ming…[et al.]. 2017. The Protective Effect of Lavender Essential Oil and Its Main Component Linalool against the Cognitive Deficits Induced by D-Galactose and Aluminum Trichloride in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1154545
Modern Language Association (MLA)
Xu, Pan…[et al.]. The Protective Effect of Lavender Essential Oil and Its Main Component Linalool against the Cognitive Deficits Induced by D-Galactose and Aluminum Trichloride in Mice. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1154545
American Medical Association (AMA)
Xu, Pan& Wang, Kezhu& Lu, Cong& Dong, Liming& Gao, Li& Yan, Ming…[et al.]. The Protective Effect of Lavender Essential Oil and Its Main Component Linalool against the Cognitive Deficits Induced by D-Galactose and Aluminum Trichloride in Mice. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1154545
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154545