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Pharmacologic Effect of Miao Medicine Illicium simonsii Maxim. on Collagen-Induced Arthritis in Rats
Joint Authors
Zhang, Qing-zhong
Hu, Xian-yun
Yao, Wen-qin
Wan, Xiao-li
Liang, Zi-cong
Dang, Rong-min
Yang, Zheng-min
Xia, Ya-lan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objectives.
To study the pharmacologic effect and mechanism of action of Miao medicine Illicium simonsii Maxim.
(ISM) in treating rheumatoid arthritis.
Methods.
Sixty rats were randomly divided to six groups: normal control (normal), collagen-induced arthritis (CIA) model (model), CIA + tripterygium glycosides (TG), CIA + ISM high dose oral (ISM-H), CIA + ISM low-dose oral (ISM-L), and CIA + ISM topical application (ISM-T).
The treatment doses were selected based on published reports and folk medicine practice.
The outcome measurements included paw swelling, joint pathology, organ index, blood count, T helper 17 (Th17) cell count, and interleukin-6 (IL-6) level.
Results.
Compared to the CIA model group, all treatment groups showed a significant reduction in paw swelling, blood vessel pathology, Th17 cell count, and IL-6 levels (p < 0.05 or p < 0.01).
All treatment groups showed alleviated foot swelling and lower total number of white blood cells, and these effects were observed earlier with oral ISM than topical ISM.
The effect of ISM was weaker than that of TG.
In addition, less organ damage was observed with topical ISM than oral ISM but better than TG.
Conclusions.
These results suggest that, by downregulating Th17 cells, ISM inhibits the production of Il-6, thereby alleviating the proliferation of endothelial and rheumatoid-like cells and leukocytosis in CIA rats, ultimately eliminating foot swelling.
American Psychological Association (APA)
Zhang, Qing-zhong& Hu, Xian-yun& Yao, Wen-qin& Wan, Xiao-li& Liang, Zi-cong& Dang, Rong-min…[et al.]. 2018. Pharmacologic Effect of Miao Medicine Illicium simonsii Maxim. on Collagen-Induced Arthritis in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1154582
Modern Language Association (MLA)
Zhang, Qing-zhong…[et al.]. Pharmacologic Effect of Miao Medicine Illicium simonsii Maxim. on Collagen-Induced Arthritis in Rats. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1154582
American Medical Association (AMA)
Zhang, Qing-zhong& Hu, Xian-yun& Yao, Wen-qin& Wan, Xiao-li& Liang, Zi-cong& Dang, Rong-min…[et al.]. Pharmacologic Effect of Miao Medicine Illicium simonsii Maxim. on Collagen-Induced Arthritis in Rats. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1154582
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154582