Aqueous Extract of Semen Ziziphi Spinosae Exerts Anxiolytic Effects during Nicotine Withdrawal via Improvement of Amygdaloid CRFCRF1R Signaling
Joint Authors
Lee, Bong Hyo
Zhao, ZhengLin
Zhao, RongJie
Gu, Changhong
Zhu, Xiaodong
Wu, Tong
Jiao, Yu
Jung, Dae Hwa
Kim, Sang Chan
Yang, Chae Ha
Lee, Chul Won
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-02
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Anxiety during nicotine withdrawal (NicW) is a key risk factor for smoking relapse.
Semen Ziziphi Spinosae (SZS), which is a prototypical hypnotic-sedative herb in Oriental medicine, has been clinically used to treat insomnia and general anxiety disorders for thousands of years.
Thus, the present study evaluated the effects of the aqueous extract of SZS (AESZS) on NicW-induced anxiety in male rats that received subcutaneous administrations of nicotine (Nic) (0.4 mg/kg, twice a day) for 7 d followed by 4 d of withdrawal.
During NicW, the rats received four intragastric treatments of AESZS (60 mg/kg/d or 180 mg/kg/d).
AESZS dose-dependently attenuated NicW-induced anxiety-like behaviors in the elevated plus maze (EPM) tests and 180 mg/kg/d AESZS inhibited NicW-induced increases in plasma corticosterone.
Additionally, the protein and mRNA expressions of corticotropin-releasing factor (CRF) and CRF type 1 receptor (CRF1R) increased in the central nucleus of the amygdala (CeA) during NicW, but these changes were suppressed by 180 mg/kg/d AESZS.
A post-AESZS infusion of CRF into the CeA abolished the attenuation of anxiety by AESZS and 180 mg/kg/d AESZS suppressed NicW-induced increases in norepinephrine and 3-methoxy-4-hydroxy-phenylglycol levels in the CeA.
The present results suggest that AESZS ameliorated NicW-induced anxiety via improvements in CRF/CRF1R and noradrenergic signaling in the CeA.
American Psychological Association (APA)
Gu, Changhong& Zhao, ZhengLin& Zhu, Xiaodong& Wu, Tong& Lee, Bong Hyo& Jiao, Yu…[et al.]. 2018. Aqueous Extract of Semen Ziziphi Spinosae Exerts Anxiolytic Effects during Nicotine Withdrawal via Improvement of Amygdaloid CRFCRF1R Signaling. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1154587
Modern Language Association (MLA)
Gu, Changhong…[et al.]. Aqueous Extract of Semen Ziziphi Spinosae Exerts Anxiolytic Effects during Nicotine Withdrawal via Improvement of Amygdaloid CRFCRF1R Signaling. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1154587
American Medical Association (AMA)
Gu, Changhong& Zhao, ZhengLin& Zhu, Xiaodong& Wu, Tong& Lee, Bong Hyo& Jiao, Yu…[et al.]. Aqueous Extract of Semen Ziziphi Spinosae Exerts Anxiolytic Effects during Nicotine Withdrawal via Improvement of Amygdaloid CRFCRF1R Signaling. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1154587
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154587