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Effects of Shizhifang on NLRP3 Inflammasome Activation and Renal Tubular Injury in Hyperuricemic Rats
Joint Authors
Xu, Lin
Ou, Jiao Ying
Huang, Di
Wu, Yan Sheng
He, Fei
He, Li Qun
Dong Gao, Jian
Wan, Qiang
Shi, Liqiang
Li, YingQiao
Wang, Huiling
Zhang, Xiaoying
Lin, Pinglan
Yang, Guanghui
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-12
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Objective.
Uric acid (UA) activates the NLRP3-ASC-caspase-1 axis and triggers cascade inflammatory that leads to hyperuricemic nephropathy and hyperuricemia-induced renal tubular injury.
The original study aims to verify the positive effects of the traditional Chinese medicinal formula Shizhifang (SZF) on ameliorating the hyperuricemia, tubular injury, and inflammasome infiltration in the kidneys of hyperuricemic lab rats.
Method.
Twenty-eight male Sprague-Dawley rats were divided into four groups: control group, oxonic acid potassium (OA) model group, OA + SZF group, and OA + Allopurinol group.
We evaluated the mediating effects of SZF on renal mitochondrial reactive oxygen species (ROS) and oxidative stress (OS) products, protein expression of NLRP3-ASC-caspase-1 axis, and downstream inflammatory factors IL-1β and IL-18 after 7 weeks of animals feeding.
Result.
SZF alleviated OA-induced hyperuricemia and inhibited OS in hyperuricemic rats ( P < 0.0 5 ).
SZF effectively suppressed the expression of gene and protein of the NLRP3-ASC-caspase-1 axis through accommodating the ROS-TXNIP pathway ( P < 0.05 ).
Conclusion.
Our data suggest that SZF alleviates renal tubular injury and inflammation infiltration by inhibiting NLRP3 inflammasome activation triggered by mitochondrial ROS in the kidneys of hyperuricemic lab rats.
American Psychological Association (APA)
Wu, Yan Sheng& He, Fei& Li, YingQiao& Wang, Huiling& Shi, Liqiang& Wan, Qiang…[et al.]. 2017. Effects of Shizhifang on NLRP3 Inflammasome Activation and Renal Tubular Injury in Hyperuricemic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-19.
https://search.emarefa.net/detail/BIM-1154593
Modern Language Association (MLA)
Wu, Yan Sheng…[et al.]. Effects of Shizhifang on NLRP3 Inflammasome Activation and Renal Tubular Injury in Hyperuricemic Rats. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-19.
https://search.emarefa.net/detail/BIM-1154593
American Medical Association (AMA)
Wu, Yan Sheng& He, Fei& Li, YingQiao& Wang, Huiling& Shi, Liqiang& Wan, Qiang…[et al.]. Effects of Shizhifang on NLRP3 Inflammasome Activation and Renal Tubular Injury in Hyperuricemic Rats. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-19.
https://search.emarefa.net/detail/BIM-1154593
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154593