Autumn Royal and Ribier Grape Juice Extracts Reduced Viability and Metastatic Potential of Colon Cancer Cells
Joint Authors
Parraga, Mario
Villena, Joan
Valenzuela, Manuel
Bastias, Lorena
Montenegro, Iván
Werner, Enrique
Madrid, Alejandro
Godoy, Patricio
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Antioxidants are known to be beneficial to health.
This paper evaluates the potential chemopreventive and anticancer properties of phenolic compounds present in grape juice extracts (GJE) from Autumn Royal and Ribier varieties.
The effects of these GJE on viability (SRB day assay) and metastatic potential (migration and invasion parameters) of colon cancer cell lines HT-29 and SW-480 were evaluated.
The effects of GJE on two matrix metalloproteinase gene expressions (MMP2 and MMP9) were also evaluated via qRT-PCR.
In the former, GJE reduced cell viability in both cell lines in a dose-dependent manner.
GJE treatment also reduced cell migration and invasion.
Moreover, MMP-2 and MMP-9 gene expression diminished depending on extract and on cell type.
Conclusions.
These results provide novel information concerning anticancer properties of selected GJE by revealing selective cytotoxicity and the ability to reduce invasiveness of colon cancer cells.
American Psychological Association (APA)
Valenzuela, Manuel& Bastias, Lorena& Montenegro, Iván& Werner, Enrique& Madrid, Alejandro& Godoy, Patricio…[et al.]. 2018. Autumn Royal and Ribier Grape Juice Extracts Reduced Viability and Metastatic Potential of Colon Cancer Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1154620
Modern Language Association (MLA)
Valenzuela, Manuel…[et al.]. Autumn Royal and Ribier Grape Juice Extracts Reduced Viability and Metastatic Potential of Colon Cancer Cells. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1154620
American Medical Association (AMA)
Valenzuela, Manuel& Bastias, Lorena& Montenegro, Iván& Werner, Enrique& Madrid, Alejandro& Godoy, Patricio…[et al.]. Autumn Royal and Ribier Grape Juice Extracts Reduced Viability and Metastatic Potential of Colon Cancer Cells. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1154620
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154620