Systematic Understanding of the Mechanism of Baicalin against Ischemic Stroke through a Network Pharmacology Approach
Joint Authors
Cheng, Fafeng
Wang, Xueqian
Ma, Chongyang
Xu, Tian
Zhang, Shuang
Fan, Shuning
Deng, Nan
Lian, Yajun
Tan, Ling
Du, Weizhe
Liu, Shuling
Ren, Beida
Li, Zhenhan
Wang, Qingguo
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Ischemic stroke is accompanied by high mortality and morbidity rates.
At present, there is no effective clinical treatment.
Alternatively, traditional Chinese medicine has been widely used in China and Japan for the treatment of ischemic stroke.
Baicalin is a flavonoid extracted from Scutellaria baicalensis that has been shown to be effective against ischemic stroke; however, its mechanism has not been fully elucidated.
Based on network pharmacology, we explored the potential mechanism of baicalin on a system level.
After obtaining baicalin structural information from the PubChem database, an approach combined with literature mining and PharmMapper prediction was used to uncover baicalin targets.
Ischemic stroke-related targets were gathered with the help of DrugBank, Online Mendelian Inheritance in Man (OMIM), Genetic Association Database (GAD), and Therapeutic Target Database (TTD).
Protein-protein interaction (PPI) networks were constructed through the Cytoscape plugin BisoGenet and analyzed by topological methods.
Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment were carried out via the Database for Annotation, Visualization, and Integrated Discovery (DAVID) server.
We obtained a total of 386 potential targets and 5 signaling pathways, including mitogen-activated protein kinase (MAPK), phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT), hypoxia-inducible factor-1 (HIF-1), nuclear factor kappa B (NF-κB), and forkhead box (FOXO) signaling pathways.
GO analysis showed that these targets were associated with antiapoptosis, antioxidative stress, anti-inflammation, and other physiopathological processes that are involved in anti-ischemic stroke effects.
In summary, the mechanism of baicalin against ischemic stroke involved multiple targets and signaling pathways.
Our study provides a network pharmacology framework for future research on traditional Chinese medicine.
American Psychological Association (APA)
Xu, Tian& Ma, Chongyang& Fan, Shuning& Deng, Nan& Lian, Yajun& Tan, Ling…[et al.]. 2018. Systematic Understanding of the Mechanism of Baicalin against Ischemic Stroke through a Network Pharmacology Approach. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1154632
Modern Language Association (MLA)
Xu, Tian…[et al.]. Systematic Understanding of the Mechanism of Baicalin against Ischemic Stroke through a Network Pharmacology Approach. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1154632
American Medical Association (AMA)
Xu, Tian& Ma, Chongyang& Fan, Shuning& Deng, Nan& Lian, Yajun& Tan, Ling…[et al.]. Systematic Understanding of the Mechanism of Baicalin against Ischemic Stroke through a Network Pharmacology Approach. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1154632
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154632