Electroacupuncture Alleviates Pain Responses and Inflammation in a Rat Model of Acute Gout Arthritis
Joint Authors
Liang, Yi
Shao, Xiao-mei
Liu, Bo-Yi
Chai, Wenxin
Tai, Yan
Wang, Ping
Zheng, Guo-qing
Fang, Jian-Qiao
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-19
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Acute gout arthritis is one of the most painful inflammatory conditions.
Treatments for gout pain are limited to colchicine, nonsteroidal anti-inflammatory drugs, and corticosteroids, which oftentimes result in severe adverse effects.
Electroacupuncture (EA) has been proved to be effective in relieving many inflammatory pain conditions with few side effects.
Here, we aim to investigate the therapeutic potentials of EA on pain and inflammation of a rat model of acute gout arthritis and underlying mechanisms.
We found that 2/100 Hz EA produced the most robust analgesic effect on mechanical hyperalgesia of acute gout arthritis rat model compared with 2 and 100 Hz.
EA produced similar analgesic effect compared with indomethacin.
2/100 Hz EA also significantly alleviates the ongoing pain behavior, thermal hyperalgesia, and ankle edema.
Locally applied μ and κ-opioid receptor antagonists but not adenosine A1 receptor antagonist significantly abolished the analgesic effect of EA.
Locally applied μ and κ-opioid receptor agonists produced significant antiallodynia on acute gout arthritis rats, mimicking EA.
Furthermore, 2/100 Hz EA upregulated β-endorphin expression in inflamed ankle skin tissue.
Our results demonstrated, for the first time, that EA can be used for relieving acute gout arthritis with effect dependent on peripheral opioid system and comparable with the one obtained with indomethacin.
American Psychological Association (APA)
Chai, Wenxin& Tai, Yan& Shao, Xiao-mei& Liang, Yi& Zheng, Guo-qing& Wang, Ping…[et al.]. 2018. Electroacupuncture Alleviates Pain Responses and Inflammation in a Rat Model of Acute Gout Arthritis. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1154635
Modern Language Association (MLA)
Chai, Wenxin…[et al.]. Electroacupuncture Alleviates Pain Responses and Inflammation in a Rat Model of Acute Gout Arthritis. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1154635
American Medical Association (AMA)
Chai, Wenxin& Tai, Yan& Shao, Xiao-mei& Liang, Yi& Zheng, Guo-qing& Wang, Ping…[et al.]. Electroacupuncture Alleviates Pain Responses and Inflammation in a Rat Model of Acute Gout Arthritis. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1154635
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154635