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Antiviral Activities of Mulberry (Morus alba) Juice and Seed against Influenza Viruses
Joint Authors
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Antiviral activities of Morus alba (MA) juice and seed were examined using time-of-addition plaque assays against influenza viruses, A/Brisbane/59/2007 (H1N1) (BR59), pandemic A/Korea/01/2009(H1N1) (KR01), A/Brisbane/10/2007(H3N2) (BR10), and B/Florida/4/2006 (FL04).
MA juice (MAJ) showed much higher antiviral activity than MA seed (MAS).
In the pre- and cotreatment of virus, MAJ showed antiviral effects against BR59, KR01, and FL04 in a dose-dependent manner.
In particular, MAJ at 4% concentration exhibited 1.3 log inhibition in the pre- and cotreatment of the virus against FL04, a type B virus.
However, little or weak inhibition was observed in the posttreatment of MAJ.
GSH levels in the virus-infected cells were also examined.
The decreased levels by the viral infection were restored significantly by the addition of MAJ.
MAJ also exhibited significant DPPH radical scavenging and ferric ion-reducing activities in a dose-dependent manner.
Cyanidin-3-rutinoside, the most abundant polyphenol compound of MAJ identified by LC-MS in this study, showed weak inhibitory effects against FL04 in the pretreatment, whereas gallic acid, a minor compound of MAJ, revealed significant antiviral effect.
These results suggest that MAJ can be developed as a novel plant-derived antiviral against influenza viruses.
American Psychological Association (APA)
Kim, Hyojin& Chung, Mi Sook. 2018. Antiviral Activities of Mulberry (Morus alba) Juice and Seed against Influenza Viruses. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1154638
Modern Language Association (MLA)
Kim, Hyojin& Chung, Mi Sook. Antiviral Activities of Mulberry (Morus alba) Juice and Seed against Influenza Viruses. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1154638
American Medical Association (AMA)
Kim, Hyojin& Chung, Mi Sook. Antiviral Activities of Mulberry (Morus alba) Juice and Seed against Influenza Viruses. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1154638
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154638