Evaluation of Antiulcer and Cytotoxic Potential of the Leaf, Flower, and Fruit Extracts of Calotropis procera and Isolation of a New Lignan Glycoside

Joint Authors

Khan, Afsar
Perveen, Shagufta
Faddah, Laila M.
Al-Taweel, Areej Mohammad
Fawzy, Ghada Ahmed
Rehman, Attiq Ur
Mehmood, Rashad

Source

Evidence-Based Complementary and Alternative Medicine

Issue

Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2017-08-30

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Medicine

Abstract EN

Calotropis procera is traditionally used for treating many diseases including ulcers and tumors.

It was thus deemed of interest to investigate and compare the antiulcer and cytotoxic activities of C.

procera leaf, flower, and fruit extracts in an attempt to verify its traditional uses.

Phytochemical studies on the fruits, flowers, and leaves of C.

procera, collected from the desert of Saudi Arabia, led to the isolation of one new lignan 7′-methoxy-3′-O-demethyl-tanegool-9-O-β-d-glucopyranoside and five known compounds from the flowers, four compounds from leaves, and a flavonoid glycoside and a lignan glycoside from the fruits.

The structures of compounds were determined by spectroscopic techniques.

Ethanol extracts of the three parts of C.

procera were evaluated for their antiulcer activity and we found that the leaf extract possessed a powerful antiulcer activity which could be considered as a promising drug candidate.

All the extracts and the isolated compounds were evaluated for their cytotoxic activity against MCF-7, HCT-116, HepG-2, and A-549 human cancer cell lines.

Compound 2 was highly active on all the cell lines, whereas compounds 5 and 11 were more selective on colon and liver cell lines.

Compound 10 demonstrated a significant activity on liver and lung cancer cell lines.

American Psychological Association (APA)

Al-Taweel, Areej Mohammad& Perveen, Shagufta& Fawzy, Ghada Ahmed& Rehman, Attiq Ur& Khan, Afsar& Mehmood, Rashad…[et al.]. 2017. Evaluation of Antiulcer and Cytotoxic Potential of the Leaf, Flower, and Fruit Extracts of Calotropis procera and Isolation of a New Lignan Glycoside. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1154659

Modern Language Association (MLA)

Al-Taweel, Areej Mohammad…[et al.]. Evaluation of Antiulcer and Cytotoxic Potential of the Leaf, Flower, and Fruit Extracts of Calotropis procera and Isolation of a New Lignan Glycoside. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1154659

American Medical Association (AMA)

Al-Taweel, Areej Mohammad& Perveen, Shagufta& Fawzy, Ghada Ahmed& Rehman, Attiq Ur& Khan, Afsar& Mehmood, Rashad…[et al.]. Evaluation of Antiulcer and Cytotoxic Potential of the Leaf, Flower, and Fruit Extracts of Calotropis procera and Isolation of a New Lignan Glycoside. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1154659

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1154659