Tongluo Zhitong Prescription Alleviates Allodynia, Hyperalgesia, and Dyskinesia in the Chronic Constriction Injury Model of Rats
Joint Authors
Wang, Jianwei
Zhang, Weiguang
Qin, Lihua
Wang, Zhi Yong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-05
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Neuropathic pain is common in clinical practice.
Exploration of new drug therapeutics has always been carried out for more satisfactory effects and fewer side-effects.
In the present study, we aimed to investigate effects of Tongluo Zhitong Prescription (TZP), a compounded Chinese medicine description, on neuropathic pain model of rats with chronic constriction injury (CCI).
The CCI model was established by loosely ligating sciatic nerve with catgut suture, proximal to its trifurcation.
The static and dynamic allodynia, heat hyperalgesia, mechanical allodynia, cold allodynia, and gait were assessed.
Our results showed that TZP alleviated CCI-induced static and dynamic allodynia, suppressed heat hyperalgesia and cold and mechanical allodynia, and improved gait function.
These results suggest that TZP could alleviate neuropathic pain.
Further experiments are needed to explore its mechanisms.
American Psychological Association (APA)
Wang, Zhi Yong& Wang, Jianwei& Qin, Lihua& Zhang, Weiguang. 2017. Tongluo Zhitong Prescription Alleviates Allodynia, Hyperalgesia, and Dyskinesia in the Chronic Constriction Injury Model of Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1154679
Modern Language Association (MLA)
Wang, Zhi Yong…[et al.]. Tongluo Zhitong Prescription Alleviates Allodynia, Hyperalgesia, and Dyskinesia in the Chronic Constriction Injury Model of Rats. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1154679
American Medical Association (AMA)
Wang, Zhi Yong& Wang, Jianwei& Qin, Lihua& Zhang, Weiguang. Tongluo Zhitong Prescription Alleviates Allodynia, Hyperalgesia, and Dyskinesia in the Chronic Constriction Injury Model of Rats. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1154679
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154679