Testicular Dysfunction Ameliorative Effect of the Methanolic Roots Extracts of Maytenus procumbens and Ozoroa paniculosa
Joint Authors
Penduka, D.
Cele, Nkosinathi David
Sangweni, Nonhlakanipho Felicia
Mosa, Rebamang Anthony
Lazarus, Geraldine Genevive
Singh, Moganavelli
Zharare, Godfrey Elijah
Opoku, Andy Rowland
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The traditional use of medicinal plants in the management of sexual dysfunctions has a long history.
This study investigated testicular dysfunction ameliorative effect of the methanolic roots extracts of Maytenus procumbens and Ozoroa paniculosa in a butanol-induced testicular dysfunction rat model.
The rats in respective experimental groups were orally administered with the extract at 50 and 250 mg/kg bw, daily for 28 days.
The cytotoxicity of the extracts was evaluated against HEK293, MCF-7, and HT29 cell lines.
The extracts exhibited moderate (LC50 30.3–330.2 μg/mL) to weak (LC50 200.8–438.4 μg/mL) cytotoxicity level on the cancer and normal cells, respectively.
While relatively lower serum testosterone levels and total sperm count along with decreased numbers of spermatogonia were noted in the untreated group, all these parameters were improved in the groups treated with the extracts at 250 mg/kg.
Improved histomorphological changes of the testes were also observed when compared to the untreated group.
While the extracts (at 250 mg/kg) increased serum reduced glutathione content and decreased malondialdehyde content, a relatively higher serum creatinine level was also observed in the treated animals group.
The results indicate that the two plant extracts have potential to ameliorate testicular dysfunction.
American Psychological Association (APA)
Cele, Nkosinathi David& Sangweni, Nonhlakanipho Felicia& Mosa, Rebamang Anthony& Penduka, D.& Lazarus, Geraldine Genevive& Singh, Moganavelli…[et al.]. 2017. Testicular Dysfunction Ameliorative Effect of the Methanolic Roots Extracts of Maytenus procumbens and Ozoroa paniculosa. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1154680
Modern Language Association (MLA)
Cele, Nkosinathi David…[et al.]. Testicular Dysfunction Ameliorative Effect of the Methanolic Roots Extracts of Maytenus procumbens and Ozoroa paniculosa. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1154680
American Medical Association (AMA)
Cele, Nkosinathi David& Sangweni, Nonhlakanipho Felicia& Mosa, Rebamang Anthony& Penduka, D.& Lazarus, Geraldine Genevive& Singh, Moganavelli…[et al.]. Testicular Dysfunction Ameliorative Effect of the Methanolic Roots Extracts of Maytenus procumbens and Ozoroa paniculosa. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1154680
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154680