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Gastroprotective Mechanism and Ulcer Resolution Effect of Cyrtocarpa procera Methanolic Extract on Ethanol-Induced Gastric Injury
Joint Authors
Cardoso-Taketa, Alexandre
Escobedo-Hinojosa, Wendy Itzel
Gomez-Chang, Erika
García-Martínez, Karina
Guerrero Alquicira, Raquel
Romero, Irma
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-09
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Gastric ulcers are a worldwide health problem and their poor healing is one of the most important causes for their recurrence.
We have previously reported the remarkable gastroprotective and anti-Helicobacter pylori activities of the methanolic extract (CpMet) of Cyrtocarpa procera bark.
This work investigates, in a murine model, the CpMet gastroprotective mechanism and establishes its preclinical efficacy in the resolution of ethanol-induced gastric ulcers.
The results showed that the gastroprotective activity of CpMet is mainly associated with endogenous NO and prostaglandins, followed by sulfhydryl groups and KATP channels.
Furthermore, CpMet (300 mg/kg, twice a day) orally administered during 20 consecutive days promoted an ulcer area reduction of 62.65% at the 20th day of the treatment.
The effect was confirmed macroscopically by the alleviation of gastric mucosal erosions and microscopically by an increase in mucin content and a reduction in the inflammatory infiltration at the site of the ulcer.
No clinical symptoms or signs of toxicity were observed in the treated animals.
The results indicate the safety and efficacy of CpMet in promoting high quality of ulcer healing by different mechanisms, but mostly through cytoprotective and anti-inflammatory effects, making it a promising phytodrug for ulcer treatment.
American Psychological Association (APA)
Escobedo-Hinojosa, Wendy Itzel& Gomez-Chang, Erika& García-Martínez, Karina& Guerrero Alquicira, Raquel& Cardoso-Taketa, Alexandre& Romero, Irma. 2018. Gastroprotective Mechanism and Ulcer Resolution Effect of Cyrtocarpa procera Methanolic Extract on Ethanol-Induced Gastric Injury. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1154687
Modern Language Association (MLA)
Escobedo-Hinojosa, Wendy Itzel…[et al.]. Gastroprotective Mechanism and Ulcer Resolution Effect of Cyrtocarpa procera Methanolic Extract on Ethanol-Induced Gastric Injury. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1154687
American Medical Association (AMA)
Escobedo-Hinojosa, Wendy Itzel& Gomez-Chang, Erika& García-Martínez, Karina& Guerrero Alquicira, Raquel& Cardoso-Taketa, Alexandre& Romero, Irma. Gastroprotective Mechanism and Ulcer Resolution Effect of Cyrtocarpa procera Methanolic Extract on Ethanol-Induced Gastric Injury. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1154687
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154687