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Ethanol Extract of Root of Prunus persica Inhibited the Growth of Liver Cancer Cell HepG2 by Inducing Cell Cycle Arrest and Migration Suppression
Joint Authors
Wang, Hong-Lian
Shen, Hongchun
Wang, Li
Wang, Lu
Zhu, Menglian
Ming, Yao
Zhao, Sha
Fan, Junming
Lai, En Yin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Liver cancer is the second most lethal cancer and hepatocellular carcinoma (HCC) is the primary cancer subgroup.
However, the current chemotherapy agents remain ineffective and present wide side effects for advanced HCC patient.
In this study, we investigated the antitumor role of ethanol extract of root of peach tree (Prunus persica (L.) Batsch and hereafter designated as TSG in short of its Chinese name), which is an important ingredient in Chinese medicine prescription, in liver cancer cell HepG2.
By cell viability assay, we showed that addition of TSG in the culture medium inhibited the cell growth of HepG2 cells in a dose and time-dependent way.
Cell cycle analysis indicated that TSG caused sustained M/G2 phase arrest.
The expression of mitosis-related protein Cdc25c was impaired upon TSG treatment.
Furthermore, wound healing assay demonstrated that TSG treatment notably suppressed the migration of HepG2 cells and the expression of extracellular matrix metalloprotease, MMP3 and MMP9.
Most significantly, administration of TSG inhibited in vivo tumor growth in nude mice.
Our findings suggested that TSG may serve as a source to isolate anti-HCC therapeutic ingredients.
American Psychological Association (APA)
Shen, Hongchun& Wang, Hong-Lian& Wang, Li& Wang, Lu& Zhu, Menglian& Ming, Yao…[et al.]. 2017. Ethanol Extract of Root of Prunus persica Inhibited the Growth of Liver Cancer Cell HepG2 by Inducing Cell Cycle Arrest and Migration Suppression. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1154688
Modern Language Association (MLA)
Shen, Hongchun…[et al.]. Ethanol Extract of Root of Prunus persica Inhibited the Growth of Liver Cancer Cell HepG2 by Inducing Cell Cycle Arrest and Migration Suppression. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1154688
American Medical Association (AMA)
Shen, Hongchun& Wang, Hong-Lian& Wang, Li& Wang, Lu& Zhu, Menglian& Ming, Yao…[et al.]. Ethanol Extract of Root of Prunus persica Inhibited the Growth of Liver Cancer Cell HepG2 by Inducing Cell Cycle Arrest and Migration Suppression. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1154688
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154688