Preventive Effects of Velvet Antler (Cervus elaphus) against Lipopolysaccharide-Induced Acute Lung Injury in Mice by Inhibiting MAPKNF-κB Activation and Inducing AMPKNrf2 Pathways
Joint Authors
Deng, Jeng-Shyan
Huang, Shyh-Shyun
Lin, Hung-Jen
Chang, Jui-Shu
Wu, Wen-Tzu
Huang, Guan-Jhong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-02
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Velvet antler (Cervus elaphus) is a typical traditional animal medicine.
It is considered to have various pharmacological effects including stimulation of the immune system, increase in the physical strength, and enhancement of sexual function.
This paper aims to investigate the aqueous extract of velvet antler (AVA) in the mouse models of LPS-induced ALI.
Inhibition of NO, TNF-α, IL-1β, IL-6, and IL-10 productions contributes to the attenuation of LPS-induced lung inflammation by AVA.
A 5-day pretreatment of AVA prevented histological alterations and enhanced antioxidant enzyme activity in lung tissues.
AVA significantly reduced the material (total number of cells and proteins) in the BALF.
Western blot analysis revealed that the expression of iNOS and COX-2 and phosphorylation of IκB-α and MAPKs proteins are blocked in LPS-stimulated macrophages as well as LPS-induced lung injury in mice.
Consistent with this concept, the phosphorylation of CaMKKβ, LKB1, AMPK, Nrf2, and HO-1 was activated after AVA treatment.
The results from this study indicate AVA has anti-inflammatory effects in vivo and AVA is a potential model for the development of health food.
In addition, its pathways may be at least partially associated with inhibiting MAPK/NF-κB activation and upregulating AMPK/Nrf2 pathways and the regulation of antioxidant enzyme activity.
American Psychological Association (APA)
Chang, Jui-Shu& Lin, Hung-Jen& Deng, Jeng-Shyan& Wu, Wen-Tzu& Huang, Shyh-Shyun& Huang, Guan-Jhong. 2018. Preventive Effects of Velvet Antler (Cervus elaphus) against Lipopolysaccharide-Induced Acute Lung Injury in Mice by Inhibiting MAPKNF-κB Activation and Inducing AMPKNrf2 Pathways. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1154689
Modern Language Association (MLA)
Chang, Jui-Shu…[et al.]. Preventive Effects of Velvet Antler (Cervus elaphus) against Lipopolysaccharide-Induced Acute Lung Injury in Mice by Inhibiting MAPKNF-κB Activation and Inducing AMPKNrf2 Pathways. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1154689
American Medical Association (AMA)
Chang, Jui-Shu& Lin, Hung-Jen& Deng, Jeng-Shyan& Wu, Wen-Tzu& Huang, Shyh-Shyun& Huang, Guan-Jhong. Preventive Effects of Velvet Antler (Cervus elaphus) against Lipopolysaccharide-Induced Acute Lung Injury in Mice by Inhibiting MAPKNF-κB Activation and Inducing AMPKNrf2 Pathways. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1154689
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154689