Astilbin from Smilax glabra Roxb. Attenuates Inflammatory Responses in Complete Freund’s Adjuvant-Induced Arthritis Rats
Joint Authors
Dong, Lisha
Zhu, Jinqiu
Du, Hongzhi
Nong, Heng
He, Xicheng
Chen, Xiaoyu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Astilbin, a flavonoid compound, was isolated from the rhizome of Smilax glabra Roxb.
(with red cross-section) grown in Guizhou Province, China.
We accessed its effect and potential mechanism on attenuation of the inflammatory response in CFA-induced AA rats.
Our results showed that daily oral administration of astilbin at 5.3 mg/kg reduced joint damage in the hind paw of AA rats.
Accordingly, astilbin exhibited remarkable inhibitory effects on TNF-α, IL-1β, and IL-6 mRNA expression.
Significant decrease of serum cytokine levels of TNF-α, IL-1β, and IL-6 was also observed in astilbin-treated AA rats compared to the vehicle-treated AA rats.
The reduced expression of these cytokines was associated with protein activity suppression of three key molecular targets in the pathogenesis of RA, including IKKβ, NF-κB p65 subunit, and TLR adaptor MyD88.
Furthermore, the therapeutic effects of astilbin on the inhibition of cytokines production as well as the reduction of inflammatory response in AA rats are close to a commonly used antirheumatic drug, leflunomide.
Collectively, our data suggest that the action mechanism of astilbin, as an anti-inflammatory agent for RA treatment, is associated with modulating the production of proinflammatory cytokines and inhibiting the expression of key elements in NF-κB signaling pathway mediated by TLR.
American Psychological Association (APA)
Dong, Lisha& Zhu, Jinqiu& Du, Hongzhi& Nong, Heng& He, Xicheng& Chen, Xiaoyu. 2017. Astilbin from Smilax glabra Roxb. Attenuates Inflammatory Responses in Complete Freund’s Adjuvant-Induced Arthritis Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1154697
Modern Language Association (MLA)
Dong, Lisha…[et al.]. Astilbin from Smilax glabra Roxb. Attenuates Inflammatory Responses in Complete Freund’s Adjuvant-Induced Arthritis Rats. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1154697
American Medical Association (AMA)
Dong, Lisha& Zhu, Jinqiu& Du, Hongzhi& Nong, Heng& He, Xicheng& Chen, Xiaoyu. Astilbin from Smilax glabra Roxb. Attenuates Inflammatory Responses in Complete Freund’s Adjuvant-Induced Arthritis Rats. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1154697
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154697