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Renoprotective Effects of Total Glucosides from Paeony against Nephrotoxicity Induced by Total Alkaloids from Semen Strychni
Joint Authors
Cheng, Yezhe
Chen, Xiaohui
Lv, Mingming
Zhang, Meiyu
Zhang, Kexia
Hou, Chenzhi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Semen Strychni have been shown to have therapeutic effect in improving blood circulation, relieving rheumatic pain, and treating cancer.
However, Semen Strychni could cause severe nephrotoxicity.
The present study was designed to evaluate whether treatment with total glucosides from paeony (TGP) has renoprotective effect against nephrotoxicity induced by total alkaloids from Semen Strychni (TAS).
The levels of blood urea nitrogen (BUN) and creatinine (Cr) were determined and histopathological changes were also examined to evaluate renal injury.
Moreover, a HPLC-MS method was developed and validated to investigate the comparative toxicokinetics of strychnine and brucine in rats plasma after oral administration of TAS and pretreatment with TGP.
Results demonstrated that the levels of BUN and Cr were significantly increased (p<0.05) in TAS group, together with tubule epithelium cloudy swelling, degeneration, and glomerular atrophy in rats’ kidneys.
The TAS-induced kidney damage was alleviated after pretreatment with TGP.
Besides, Tmax of strychnine and brucine were increased and T1/2 of strychnine and brucine were decreased after pretreatment with TGP.
The toxicokinetics study showed that pretreatment with TGP could attenuate the absorption of strychnine and brucine, as well as accelerate their elimination.
These results suggest that TGP possesses renoprotective effects.
American Psychological Association (APA)
Lv, Mingming& Zhang, Meiyu& Cheng, Yezhe& Zhang, Kexia& Hou, Chenzhi& Chen, Xiaohui. 2017. Renoprotective Effects of Total Glucosides from Paeony against Nephrotoxicity Induced by Total Alkaloids from Semen Strychni. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1154701
Modern Language Association (MLA)
Lv, Mingming…[et al.]. Renoprotective Effects of Total Glucosides from Paeony against Nephrotoxicity Induced by Total Alkaloids from Semen Strychni. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1154701
American Medical Association (AMA)
Lv, Mingming& Zhang, Meiyu& Cheng, Yezhe& Zhang, Kexia& Hou, Chenzhi& Chen, Xiaohui. Renoprotective Effects of Total Glucosides from Paeony against Nephrotoxicity Induced by Total Alkaloids from Semen Strychni. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1154701
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154701