Chronic Unpredictable Mild Stress Aggravates Mood Disorder, Cognitive Impairment, and Brain Insulin Resistance in Diabetic Rat
Joint Authors
Wang, YuHong
Yang, Hui
Li, Wei
Meng, Pan
Liu, Zhuo
Liu, Jian
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Diabetes-induced brain insulin resistance is associated with many mental diseases, including depression.
Epidemiological evidences demonstrate the pathophysiologic link between stress, depression, and diabetes.
This study was designed to determine whether chronic unpredictable mild stress- (CUMS-) induced changes in brain insulin resistance could contribute to deterioration in mood and cognitive functions in diabetic rats.
Male SD rats were randomly assigned to three groups, including standard control group, the diabetes group, and the diabetes with CUMS group.
After 7 weeks, emotional behaviors and memory performances as well as metabolic phenotypes were measured.
In addition, we examined the changes in protein expression related to brain insulin signaling.
Our results show that rats in diabetes with CUMS group displayed a decreased locomotor behavior in open-field test, an increased immobility time in forced swim test, and tail suspension test, and an impaired learning and memory in the Morris water maze when compared to animals in diabetes group.
Further, diabetes with CUMS exhibited a significant decrease in phosphorylation of insulin receptor and an increase phosphorylation of IRS-1 in brain.
These results suggest that the depression-like behaviors and cognitive function impairments in diabetic rats with CUMS were related to the changes of brain insulin signaling.
American Psychological Association (APA)
Yang, Hui& Li, Wei& Meng, Pan& Liu, Zhuo& Liu, Jian& Wang, YuHong. 2018. Chronic Unpredictable Mild Stress Aggravates Mood Disorder, Cognitive Impairment, and Brain Insulin Resistance in Diabetic Rat. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1154702
Modern Language Association (MLA)
Yang, Hui…[et al.]. Chronic Unpredictable Mild Stress Aggravates Mood Disorder, Cognitive Impairment, and Brain Insulin Resistance in Diabetic Rat. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1154702
American Medical Association (AMA)
Yang, Hui& Li, Wei& Meng, Pan& Liu, Zhuo& Liu, Jian& Wang, YuHong. Chronic Unpredictable Mild Stress Aggravates Mood Disorder, Cognitive Impairment, and Brain Insulin Resistance in Diabetic Rat. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1154702
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154702