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Effects of the Fruit Extract of Tribulus terrestris on Skin Inflammation in Mice with Oxazolone-Induced Atopic Dermatitis through Regulation of Calcium Channels, Orai-1 and TRPV3, and Mast Cell Activation
Joint Authors
Kim, Young Ho
Kang, Seok Yong
Nam, Joo Hyun
Kim, Woo Kyung
Kang, Jong-Seong
Cho, Cheong-Weon
Cho, Chong Woon
Park, Yong-Ki
Bae, Hyo Sang
Jung, Hyo Won
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Ethnopharmacological Relevance.
In this study, we investigated the effects of Tribulus terrestris fruit (Leguminosae, Tribuli Fructus, TF) extract on oxazolone-induced atopic dermatitis in mice.
Materials and Methods.
TF extract was prepared with 30% ethanol as solvent.
The 1% TF extract with or without 0.1% HC was applied to the back skin daily for 24 days.
Results.
1% TF extract with 0.1% HC improved AD symptoms and reduced TEWL and symptom scores in AD mice.
1% TF extract with 0.1% HC inhibited skin inflammation through decrease in inflammatory cells infiltration as well as inhibition of Orai-1 expression in skin tissues.
TF extract inhibited Orai-1 activity in Orai-1-STIM1 cooverexpressing HEK293T cells but increased TRPV3 activity in TRPV3-overexpressing HEK293T cells.
TF extract decreased β-hexosaminidase release in RBL-2H3 cells.
Conclusions.
The present study demonstrates that the topical application of TF extract improves skin inflammation in AD mice, and the mechanism for this effect appears to be related to the modulation of calcium channels and mast cell activation.
This outcome suggests that the combination of TF and steroids could be a more effective and safe approach for AD treatment.
American Psychological Association (APA)
Kang, Seok Yong& Jung, Hyo Won& Nam, Joo Hyun& Kim, Woo Kyung& Kang, Jong-Seong& Kim, Young Ho…[et al.]. 2017. Effects of the Fruit Extract of Tribulus terrestris on Skin Inflammation in Mice with Oxazolone-Induced Atopic Dermatitis through Regulation of Calcium Channels, Orai-1 and TRPV3, and Mast Cell Activation. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1154716
Modern Language Association (MLA)
Kang, Seok Yong…[et al.]. Effects of the Fruit Extract of Tribulus terrestris on Skin Inflammation in Mice with Oxazolone-Induced Atopic Dermatitis through Regulation of Calcium Channels, Orai-1 and TRPV3, and Mast Cell Activation. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1154716
American Medical Association (AMA)
Kang, Seok Yong& Jung, Hyo Won& Nam, Joo Hyun& Kim, Woo Kyung& Kang, Jong-Seong& Kim, Young Ho…[et al.]. Effects of the Fruit Extract of Tribulus terrestris on Skin Inflammation in Mice with Oxazolone-Induced Atopic Dermatitis through Regulation of Calcium Channels, Orai-1 and TRPV3, and Mast Cell Activation. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1154716
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154716