Experimental Study of Phlebitis Ointment Administration in Acute Superficial Thrombophlebitis
Joint Authors
Li, Guangzong
Pang, He
Yang, Baozhong
Litscher, Daniela
Wang, Lu
Litscher, Gerhard
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Acute superficial thrombophlebitis is a venous system disease.
Animal models with mannitol induced phlebitis were treated with an orally administered “phlebitis ointment.” 24 rabbits were randomly divided into 4 groups.
The therapy group was treated with “phlebitis ointment” and a control group received “Mai Luo Shu Tong granules.” Levels of blood TNF-α, IL-6, CRP, and IL-1β were measured.
The tissue expression levels of NF-КBp65 and PKC genes were evaluated.
The therapy group showed a better improvement of the clinical status and similar vascular morphology than the control group.
A blank group showed no vascular changes through pathological investigation.
In contrast, significant vascular changes were seen in the model group.
The control group showed slight vascular modifications.
Small thrombi could be found in the lumen despite the intact tunica intima.
Both control and therapy group showed less inflammatory cells infiltration than the model group and upregulation of NF-КBp65 and PKC genes.
The phlebitis ointment reduced the levels of necrosis factor-α, interleukin-6, C-reactive protein, and interleukin-1ß.
The expressions of NF-КBp65 and PKC genes, which are the primary mechanisms underlying the development of thrombophlebitis, were improved significantly in tissues of both therapy group and control group.
American Psychological Association (APA)
Li, Guangzong& Litscher, Gerhard& Pang, He& Yang, Baozhong& Litscher, Daniela& Wang, Lu. 2018. Experimental Study of Phlebitis Ointment Administration in Acute Superficial Thrombophlebitis. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1154729
Modern Language Association (MLA)
Li, Guangzong…[et al.]. Experimental Study of Phlebitis Ointment Administration in Acute Superficial Thrombophlebitis. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1154729
American Medical Association (AMA)
Li, Guangzong& Litscher, Gerhard& Pang, He& Yang, Baozhong& Litscher, Daniela& Wang, Lu. Experimental Study of Phlebitis Ointment Administration in Acute Superficial Thrombophlebitis. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1154729
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154729