Xuebijing Injection Combined with Antibiotics for the Treatment of Spontaneous Bacterial Peritonitis in Liver Cirrhosis: A Meta-Analysis
Joint Authors
Guo, Xiaozhong
Romeiro, Fernando Gomes
Mancuso, Andrea
Li, Yingying
Han, Bing
Song, Tingxue
Bao, Wenchun
Wang, Ran
Bai, Zhaohui
Zheng, Kexin
Li, Qianqian
Han, Dan
Yu, Yang
Teschke, Rolf
Peng, Zhong
Zhou, Xinmiao
Sun, Ming-yu
Qi, Xingshun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background and Aim.
Spontaneous bacterial peritonitis (SBP) is one of the most common complications of liver cirrhosis.
Antibiotics are the main treatment regimen of SBP.
Traditional Chinese medicine Xuebijing injection has been used in such patients.
Our study aimed to overview the efficacy of Xuebijing injection combined with antibiotics for the treatment of SBP.
Method.
We searched the PubMed, Embase, China National Knowledge Infrastructure, VIP, and Wanfang databases.
The search items included “Xuebijing”, “peritonitis”, “liver cirrhosis”, and “random” to identify all relevant randomized controlled trials (RCTs).
The Cochrane risk of bias tool was used to assess the study quality.
The odd ratios (ORs) with 95% confidence intervals (CIs) were calculated by using a random-effect model.
Heterogeneity was also calculated.
Results.
A total of 9 RCTs were included.
The study quality was unsatisfied.
The overall (OR = 2.95, 95% CI = 1.97–4.42, p<0.00001) and complete (OR = 2.18, 95% CI = 1.57–3.04, p<0.00001) responses were significantly higher in the Xuebijing injection combined with antibiotics group than the antibiotics alone group.
The incidence of cirrhosis related complications, including hepatic encephalopathy and hepatorenal syndrome, was lower in the Xuebijing injection combined with antibiotics group than the antibiotics alone group.
No significant heterogeneity was observed among studies.
Conclusion.
Additional use of Xuebijing injection may improve the efficacy of antibiotics for the treatment of SBP in liver cirrhosis.
However, due to a low level of current evidence, we did not establish any recommendation regarding the use of Xuebijing injection for the treatment of SBP.
American Psychological Association (APA)
Han, Dan& Wang, Ran& Yu, Yang& Sun, Ming-yu& Teschke, Rolf& Romeiro, Fernando Gomes…[et al.]. 2018. Xuebijing Injection Combined with Antibiotics for the Treatment of Spontaneous Bacterial Peritonitis in Liver Cirrhosis: A Meta-Analysis. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1154734
Modern Language Association (MLA)
Han, Dan…[et al.]. Xuebijing Injection Combined with Antibiotics for the Treatment of Spontaneous Bacterial Peritonitis in Liver Cirrhosis: A Meta-Analysis. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1154734
American Medical Association (AMA)
Han, Dan& Wang, Ran& Yu, Yang& Sun, Ming-yu& Teschke, Rolf& Romeiro, Fernando Gomes…[et al.]. Xuebijing Injection Combined with Antibiotics for the Treatment of Spontaneous Bacterial Peritonitis in Liver Cirrhosis: A Meta-Analysis. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1154734
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154734