Total Flavonoids from Oroxylum indicum Induce Apoptosis via PI3KAktPTEN Signaling Pathway in Liver Cancer
Joint Authors
Li, Nan-nan
Meng, Xian-sheng
Men, Wen-xiao
Bao, Yong-rui
Wang, Shuai
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Total flavonoids (TF), derived from the seeds of Oroxylum indicum (L.) Vent., possess many pharmacological functions.
In the present study, H22-bearing mice and SMMC-7721 models were employed to evaluate the antitumor activity of TF and to and investigate its possible mechanisms both in vitro and in vivo.
Cell viability was evaluated by MTT assay; cell apoptosis rate was analyzed via Annexin V-FITC/PI double staining by flow cytometer.
Meanwhile, the expressions of apoptosis-related mRNA and proteins were evaluated by RT-PCR and Western blot analysis.
The results revealed that TF could significantly inhibit the tumor growth, and the possible mechanism was related to the effect of inducing tumor cells apoptosis through PI3K/Akt/PTEN signaling pathway.
This study has provided a theoretical basis for the further development and application of TF as antitumor drugs.
American Psychological Association (APA)
Li, Nan-nan& Meng, Xian-sheng& Men, Wen-xiao& Bao, Yong-rui& Wang, Shuai. 2018. Total Flavonoids from Oroxylum indicum Induce Apoptosis via PI3KAktPTEN Signaling Pathway in Liver Cancer. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1154740
Modern Language Association (MLA)
Li, Nan-nan…[et al.]. Total Flavonoids from Oroxylum indicum Induce Apoptosis via PI3KAktPTEN Signaling Pathway in Liver Cancer. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1154740
American Medical Association (AMA)
Li, Nan-nan& Meng, Xian-sheng& Men, Wen-xiao& Bao, Yong-rui& Wang, Shuai. Total Flavonoids from Oroxylum indicum Induce Apoptosis via PI3KAktPTEN Signaling Pathway in Liver Cancer. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1154740
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154740