Antidiarrheal Activity of 80% Methanolic Leaf Extract of Justicia schimperiana
Joint Authors
Asrie, Assefa Belay
Mekonnen, Belay
Wubneh, Zewdu Birhanu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-06
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Diarrhea is one of the leading causes of preventable death in developing countries and mainly affects children and infants.
It has been reported that the leaf of Justicia schimperiana is used as an antidiarrheal agent in Libo Kemekem district, northwest Ethiopia.
Method.
The 80% methanolic leaf extract of J.
schimperiana was evaluated for its activity against castor oil-induced diarrhea, enteropooling, and gastrointestinal motility in mice.
Results.
Significant reduction (p<0.001) in the total defecation and diarrheal drops was produced by all the test doses of the extract.
Percentage inhibition of wet feces was 42.58, 65.07, and 74.96% at 100, 200, and 400 mg/kg doses of the extract, respectively.
The extract also significantly inhibited castor oil-induced enteropooling at all test doses.
The percent reduction in mean weight of intestinal contents was 66.96, 67.83, and 76.52% at 100, 200, and 400 mg/kg doses of the extract, respectively.
The extract significantly reduced gastrointestinal movement of charcoal meal as well at 200 (p<0.01) and 400 mg/kg (p<0.001) doses.
Conclusion.
In conclusion, the methanolic leaf extract of J.
schimperiana has an antidiarrheal activity and this supports the use of this plant in the treatment of diarrhea in the traditional settings.
American Psychological Association (APA)
Mekonnen, Belay& Asrie, Assefa Belay& Wubneh, Zewdu Birhanu. 2018. Antidiarrheal Activity of 80% Methanolic Leaf Extract of Justicia schimperiana. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1154752
Modern Language Association (MLA)
Mekonnen, Belay…[et al.]. Antidiarrheal Activity of 80% Methanolic Leaf Extract of Justicia schimperiana. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1154752
American Medical Association (AMA)
Mekonnen, Belay& Asrie, Assefa Belay& Wubneh, Zewdu Birhanu. Antidiarrheal Activity of 80% Methanolic Leaf Extract of Justicia schimperiana. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1154752
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154752