![](/images/graphics-bg.png)
Network Pharmacology Study on the Pharmacological Mechanism of Cinobufotalin Injection against Lung Cancer
Joint Authors
Mao, Yun
Peng, Xi
Xue, Peng
Lu, Dianrong
Li, Linlu
Zhu, Shijie
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-17
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Cinobufotalin injection, extracted from the skin of Chinese giant salamander or black sable, has good clinical effect against lung cancer.
However, owing to its complex composition, the pharmacological mechanism of cinobufotalin injection has not been fully clarified.
This study aimed to explore the mechanism of action of cinobufotalin injection against lung cancer using network pharmacology and bioinformatics.
Compounds of cinobufotalin injection were determined by literature retrieval, and potential therapeutic targets of cinobufotalin injection were screened from Swiss Target Prediction and STITCH databases.
Lung-cancer-related genes were summarized from GeneCards, OMIM, and DrugBank databases.
The pharmacological mechanism of cinobufotalin injection against lung cancer was determined by enrichment analysis of gene ontology and Kyoto Encyclopedia of Genes and Genomes, and protein-protein interaction network was constructed.
We identified 23 compounds and 506 potential therapeutic targets of cinobufotalin injection, as well as 70 genes as potential therapeutic targets of cinobufotalin injection in lung cancer by molecular docking.
The antilung cancer effect of cinobufotalin injection was shown to involve cell cycle, cell proliferation, antiangiogenesis effect, and immune inflammation pathways, such as PI3K-Akt, VEGF, and the Toll-like receptor signaling pathway.
In network analysis, the hub targets of cinobufotalin injection against lung cancer were identified as VEGFA, EGFR, CCND1, CASP3, and AKT1.
A network diagram of “drug-compounds-target-pathway” was constructed through network pharmacology to elucidate the pharmacological mechanism of the antilung cancer effect of cinobufotalin injection, which is conducive to guiding clinical medication.
American Psychological Association (APA)
Mao, Yun& Peng, Xi& Xue, Peng& Lu, Dianrong& Li, Linlu& Zhu, Shijie. 2020. Network Pharmacology Study on the Pharmacological Mechanism of Cinobufotalin Injection against Lung Cancer. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1154753
Modern Language Association (MLA)
Mao, Yun…[et al.]. Network Pharmacology Study on the Pharmacological Mechanism of Cinobufotalin Injection against Lung Cancer. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1154753
American Medical Association (AMA)
Mao, Yun& Peng, Xi& Xue, Peng& Lu, Dianrong& Li, Linlu& Zhu, Shijie. Network Pharmacology Study on the Pharmacological Mechanism of Cinobufotalin Injection against Lung Cancer. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1154753
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154753