Passiflora cincinnata Extract Delays the Development of Motor Signs and Prevents Dopaminergic Loss in a Mice Model of Parkinson’s Disease
Joint Authors
Estevam, Charles Santos
Santos, Jose Ronaldo dos
Engelberth, Rovena Clara G. J.
Cavalcante, Jeferson Sousa
Marchioro, M.
Brandão, Luiz Eduardo Mateus
Nôga, Diana Aline Morais Ferreira
Dierschnabel, Aline Lima
Campêlo, Clarissa Loureiro das Chagas
Meurer, Ywlliane da Silva Rodrigues
Lima, Ramón Hypolito
Lima, Clésio Andrade
Silva, Regina Helena
Ribeiro, Alessandra Mussi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Passiflora cincinnata Masters is a Brazilian native species of passionflower.
This genus is known in the American continent folk medicine for its diuretic and analgesic properties.
Nevertheless, few studies investigated possible biological effects of P.
cincinnata extracts.
Further, evidence of antioxidant actions encourages the investigation of possible neuroprotective effects in animal models of neurodegenerative diseases.
This study investigates the effect of the P.
cincinnata ethanolic extract (PAS) on mice submitted to a progressive model of Parkinson’s disease (PD) induced by reserpine.
Male (6-month-old) mice received reserpine (0.1 mg/kg, s.c.), every other day, for 40 days, with or without a concomitant treatment with daily injections of PAS (25 mg/kg, i.p.).
Catalepsy, open field, oral movements, and plus-maze discriminative avoidance evaluations were performed across treatment, and immunohistochemistry for tyrosine hydroxylase was conducted at the end.
The results showed that PAS treatment delayed the onset of motor impairments and prevented the occurrence of increased catalepsy behavior in the premotor phase.
However, PAS administration did not modify reserpine-induced cognitive impairments.
Moreover, PAS prevented the decrease in tyrosine hydroxylase immunostaining in the substantia nigra pars compacta (SNpc) induced by reserpine.
Taken together, our results suggested that PAS exerted a neuroprotective effect in a progressive model of PD.
American Psychological Association (APA)
Brandão, Luiz Eduardo Mateus& Nôga, Diana Aline Morais Ferreira& Dierschnabel, Aline Lima& Campêlo, Clarissa Loureiro das Chagas& Meurer, Ywlliane da Silva Rodrigues& Lima, Ramón Hypolito…[et al.]. 2017. Passiflora cincinnata Extract Delays the Development of Motor Signs and Prevents Dopaminergic Loss in a Mice Model of Parkinson’s Disease. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1154761
Modern Language Association (MLA)
Brandão, Luiz Eduardo Mateus…[et al.]. Passiflora cincinnata Extract Delays the Development of Motor Signs and Prevents Dopaminergic Loss in a Mice Model of Parkinson’s Disease. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1154761
American Medical Association (AMA)
Brandão, Luiz Eduardo Mateus& Nôga, Diana Aline Morais Ferreira& Dierschnabel, Aline Lima& Campêlo, Clarissa Loureiro das Chagas& Meurer, Ywlliane da Silva Rodrigues& Lima, Ramón Hypolito…[et al.]. Passiflora cincinnata Extract Delays the Development of Motor Signs and Prevents Dopaminergic Loss in a Mice Model of Parkinson’s Disease. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1154761
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154761