Zanthoxylum ailanthoides Suppresses Oleic Acid-Induced Lipid Accumulation through an Activation of LKB1AMPK Pathway in HepG2 Cells
Joint Authors
Lee, Mi Kyeong
Kwon, Eun-Bin
Kang, Myung-Ji
Kim, Soo-Yeon
Yuk, Heung Joo
Ryu, Hyung Won
Lee, Su Ui
Moon, Dong-Oh
Lee, Hyun-Sun
Kim, Mun-Ock
Oh, Sei-Ryang
Lee, Yong Moon
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-08
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Zanthoxylum ailanthoides (ZA) has been used as folk medicines in East Asian and recently reported to have several bioactivity; however, the studies of ZA on the regulation of triacylglycerol (TG) biosynthesis have not been elucidated yet.
In this study, we examined whether the methanol extract of ZA (ZA-M) could reduce oleic acid- (OA-) induced intracellular lipid accumulation and confirmed its mode of action in HepG2 cells.
ZA-M was shown to promote the phosphorylation of AMPK and its upstream LKB1, followed by reduction of lipogenic gene expressions.
As a result, treatment of ZA-M blocked de novo TG biosynthesis and subsequently mitigated intracellular neutral lipid accumulation in HepG2 cells.
ZA-M also inhibited OA-induced production of reactive oxygen species (ROS) and TNF-α, suggesting that ZA-M possess the anti-inflammatory feature in fatty acid over accumulated condition.
Taken together, these results suggest that ZA-M attenuates OA-induced lipid accumulation and inflammation through the activation of LKB1/AMPK signaling pathway in HepG2 cells.
American Psychological Association (APA)
Kwon, Eun-Bin& Kang, Myung-Ji& Kim, Soo-Yeon& Lee, Yong Moon& Lee, Mi Kyeong& Yuk, Heung Joo…[et al.]. 2018. Zanthoxylum ailanthoides Suppresses Oleic Acid-Induced Lipid Accumulation through an Activation of LKB1AMPK Pathway in HepG2 Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1154775
Modern Language Association (MLA)
Kwon, Eun-Bin…[et al.]. Zanthoxylum ailanthoides Suppresses Oleic Acid-Induced Lipid Accumulation through an Activation of LKB1AMPK Pathway in HepG2 Cells. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1154775
American Medical Association (AMA)
Kwon, Eun-Bin& Kang, Myung-Ji& Kim, Soo-Yeon& Lee, Yong Moon& Lee, Mi Kyeong& Yuk, Heung Joo…[et al.]. Zanthoxylum ailanthoides Suppresses Oleic Acid-Induced Lipid Accumulation through an Activation of LKB1AMPK Pathway in HepG2 Cells. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1154775
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154775