Effectiveness of Aqueous Extract of Marine Baitworm Marphysa moribidii Idris, Hutchings and Arshad, 2014 (Annelida, Polychaeta), on Acute Wound Healing Using Sprague Dawley Rats
Joint Authors
Rapi, Hannah Syahirah
Che Soh, Nor ‘Awatif
Mohd Azam, Nurul Shahirah
Maulidiani, M.
Assaw, Suvik
Haron, Mohd Nizam
Idris, Izwandy
Ismail, Wan Iryani Wan
Ali, Abdul Manaf
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-25
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Wound healing is a well-coordinated process that restores skin integrity upon injury.
However, some wound treatment poses harmful effects on the skin, which delay the normal wound healing process.
Marphysa moribidii, a marine baitworm or polychaete, represents unique ability to regenerate posterior segment after injury, which may be beneficial in the wound healing treatment.
The effectiveness of the polychaete as wound healing treatment was discovered through skin irritation, microbial testing, animal wound model, and chemical identifications.
Three polychaete extracts (PE) emulsifying ointment (0.1%, 0.5%, and 1.0%) were topically applied to the full thickness wound model once daily for 14 days.
Interestingly, PE 1.0% revealed the most rapid wound healing effects as compared to other treatments, including gamat (sea cucumber) oil (15% w/v) and acriflavine (0.1% w/v).
Histopathological analysis using Masson’s trichrome staining further confirms that PE treated wound exhibited minimal scar, high collagen deposition, and the emergence of neovascularisation.
The extract also displayed a minimum inhibitory concentration (MIC) of 0.4 g/ml against Escherichia coli and absence of skin irritation, infectious bacteria, and heavy metals from the extract.
Moreover, chemical compounds such as alkaloid, flavonoid, amino acids, and organic acid were detected in M.
moribidii extracts, which could contribute to wound healing activity.
In conclusion, this study further justifies the beneficial use of polychaete in treating wound healing and could be developed as a novel bioactive agent in nutraceuticals and pharmaceutical drugs.
American Psychological Association (APA)
Rapi, Hannah Syahirah& Che Soh, Nor ‘Awatif& Mohd Azam, Nurul Shahirah& Maulidiani, M.& Assaw, Suvik& Haron, Mohd Nizam…[et al.]. 2020. Effectiveness of Aqueous Extract of Marine Baitworm Marphysa moribidii Idris, Hutchings and Arshad, 2014 (Annelida, Polychaeta), on Acute Wound Healing Using Sprague Dawley Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1154803
Modern Language Association (MLA)
Rapi, Hannah Syahirah…[et al.]. Effectiveness of Aqueous Extract of Marine Baitworm Marphysa moribidii Idris, Hutchings and Arshad, 2014 (Annelida, Polychaeta), on Acute Wound Healing Using Sprague Dawley Rats. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1154803
American Medical Association (AMA)
Rapi, Hannah Syahirah& Che Soh, Nor ‘Awatif& Mohd Azam, Nurul Shahirah& Maulidiani, M.& Assaw, Suvik& Haron, Mohd Nizam…[et al.]. Effectiveness of Aqueous Extract of Marine Baitworm Marphysa moribidii Idris, Hutchings and Arshad, 2014 (Annelida, Polychaeta), on Acute Wound Healing Using Sprague Dawley Rats. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1154803
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154803