Compound Schisandra-Ginseng-Notoginseng-Lycium Extract Ameliorates Scopolamine-Induced Learning and Memory Disorders in Mice
Joint Authors
Li, Ning
Liu, Cong
Jing, Shu
Wang, Mengyang
Wang, Han
Sun, Jinghui
Chen, Jianguang
Li, He
Wang, Chun-Mei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Schisandra, Ginseng, Notoginseng, and Lycium barbarum are traditional Chinese medicinal plants sharing cognitive-enhancing properties.
To design a functional food to improve memory, we prepared a compound Schisandra-Ginseng-Notoginseng-Lycium (CSGNL) extract and investigated its effect on scopolamine-induced learning and memory loss in mice.
To optimize the dose ratios of the four herbal extracts in CSGNL, orthogonal experiments were performed.
Mice were administered CSGNL by gavage once a day for 30 days and then mouse learning and memory were evaluated by Morris water maze and step-through tests.
The mechanisms of CSGNL improving learning and memory were investigated by assaying acetylcholine (ACh) levels and choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) activities in the brain tissues of treated mice.
The results showed that CSGNL significantly ameliorated scopolamine-induced learning and memory impairment, at least in part, by modulating ACh levels and ChAT and AChE activities in the mouse brain.
Our data support the use of CSGNL as a functional food for learning and memory enhancement.
American Psychological Association (APA)
Li, Ning& Liu, Cong& Jing, Shu& Wang, Mengyang& Wang, Han& Sun, Jinghui…[et al.]. 2017. Compound Schisandra-Ginseng-Notoginseng-Lycium Extract Ameliorates Scopolamine-Induced Learning and Memory Disorders in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1154808
Modern Language Association (MLA)
Li, Ning…[et al.]. Compound Schisandra-Ginseng-Notoginseng-Lycium Extract Ameliorates Scopolamine-Induced Learning and Memory Disorders in Mice. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1154808
American Medical Association (AMA)
Li, Ning& Liu, Cong& Jing, Shu& Wang, Mengyang& Wang, Han& Sun, Jinghui…[et al.]. Compound Schisandra-Ginseng-Notoginseng-Lycium Extract Ameliorates Scopolamine-Induced Learning and Memory Disorders in Mice. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1154808
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154808