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Study of the Hypoglycemic Activity of Derivatives of Isoflavones from Cicer arietinum L.
Joint Authors
Sun, Wen
Xu, Tunhai
Wei, Ying
Li, Pengshou
Li, Bo
Gao, Jiaqi
Wang, Dongchao
Qin, Lingling
Xu, Yunling
Shi, Haoxia
Liu, Tonghua
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-21
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
The chickpea, a food and medicine used by the people of Xinjiang, has a beneficial hypoglycemic effect.
To better utilize this national resource and develop hypoglycemic agents from components of the chickpea, a series of new derivatives of isoflavone compounds from the chickpea were synthesized.
An insulin-resistant (IR) HepG2 cell model was used to screen the hypoglycemic activities of these compounds.
And the structure-activity relationships of these compounds were explored.
Additionally, several combinations of these compound displayed higher hypoglycemic activity than any single compound, and they had similar hypoglycemic activity to that of the positive control group (p>0.05).
In addition, combination 3 and combination 6 exerted different effects on the insulin sensitivity of H4IIE cells stimulated with resistin.
And the results indicated that combination 3 would have higher hypoglycemic activity.
These findings demonstrate the characteristics of multiple components and targets of Chinese herbal medicine.
This evidence may provide new ideas for the development of hypoglycemic drugs.
American Psychological Association (APA)
Wei, Ying& Li, Pengshou& Li, Bo& Gao, Jiaqi& Wang, Dongchao& Qin, Lingling…[et al.]. 2017. Study of the Hypoglycemic Activity of Derivatives of Isoflavones from Cicer arietinum L.. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1154839
Modern Language Association (MLA)
Wei, Ying…[et al.]. Study of the Hypoglycemic Activity of Derivatives of Isoflavones from Cicer arietinum L.. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-18.
https://search.emarefa.net/detail/BIM-1154839
American Medical Association (AMA)
Wei, Ying& Li, Pengshou& Li, Bo& Gao, Jiaqi& Wang, Dongchao& Qin, Lingling…[et al.]. Study of the Hypoglycemic Activity of Derivatives of Isoflavones from Cicer arietinum L.. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1154839
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154839