Efficacy and Safety of Sipjeondaebo-Tang for Anorexia in Patients with Cancer: A Pilot, Randomized, Double-Blind, Placebo-Controlled Trial
Joint Authors
Ko, Seong-Gyu
Shin, Yong Cheol
Cheon, Chunhoo
Kim, Mia
Yoo, Jeong-Eun
Cho, Chong-Kwan
Kang, Sohyeon
Jang, Bo-Hyoung
Yoo, Hwa-Seung
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Anorexia occurs in about half of cancer patients and is associated with high mortality rate.
However, safe and long-term use of anorexia treatment is still an unmet need.
Objective.
The purpose of the present study was to examine the feasibility of Sipjeondaebo-tang (Juzen-taiho-to, Shi-Quan-Da-Bu-Tang) for cancer-related anorexia.
Methods.
A total of 32 participants with cancer anorexia were randomized to either Sipjeondaebo-tang group or placebo group.
Participants were given 3 g of Sipjeondaebo-tang or placebo 3 times a day for 4 weeks.
The primary outcome was a change in the Anorexia/Cachexia Subscale of Functional Assessment of Anorexia/Cachexia Therapy (FAACT).
The secondary outcomes included Visual Analogue Scale (VAS) of anorexia, FAACT scale, and laboratory tests.
Results.
Anorexia and quality of life measured by FAACT and VAS were improved after 4 weeks of Sipjeondaebo-tang treatment.
However, there was no significant difference between changes of Sipjeondaebo-tang group and placebo group.
Conclusions.
Sipjeondaebo-tang appears to have potential benefit for anorexia management in patients with cancer.
Further large-scale studies are needed to ensure the efficacy.
Trial Registration.
This trial is registered with ClinicalTrials.gov NCT02468141.
American Psychological Association (APA)
Cheon, Chunhoo& Yoo, Jeong-Eun& Yoo, Hwa-Seung& Cho, Chong-Kwan& Kang, Sohyeon& Kim, Mia…[et al.]. 2017. Efficacy and Safety of Sipjeondaebo-Tang for Anorexia in Patients with Cancer: A Pilot, Randomized, Double-Blind, Placebo-Controlled Trial. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1154846
Modern Language Association (MLA)
Cheon, Chunhoo…[et al.]. Efficacy and Safety of Sipjeondaebo-Tang for Anorexia in Patients with Cancer: A Pilot, Randomized, Double-Blind, Placebo-Controlled Trial. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1154846
American Medical Association (AMA)
Cheon, Chunhoo& Yoo, Jeong-Eun& Yoo, Hwa-Seung& Cho, Chong-Kwan& Kang, Sohyeon& Kim, Mia…[et al.]. Efficacy and Safety of Sipjeondaebo-Tang for Anorexia in Patients with Cancer: A Pilot, Randomized, Double-Blind, Placebo-Controlled Trial. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1154846
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154846