Fuling-Guizhi Herb Pair in Coronary Heart Disease: Integrating Network Pharmacology and In Vivo Pharmacological Evaluation
Joint Authors
Ming, Shu-ping
Tian, Guangyu
Huang, Fang
Li, Jingjing
Wang, Qiong
Duan, Bailu
Han, Lintao
Zhang, Dongning
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The Fuling (Poria cocos)-Guizhi (Cinnamomi ramulus) herb pair (FGHP) is a commonly used traditional Chinese herbal formula with coronary heart disease (CHD) treatment potential.
However, the mechanism of FGHP in the treatment of CHD was still unclear.
In this study, the action targets and underlying mechanism of FGHP against CHD were successfully achieved by combined network pharmacology prediction with experimental verification.
76 common targets were screened out by overlapping the chemical-protein data of FGHP and CHD-related targets.
Then, two key targets were further selected for verification by using western blot analysis after analyzing PPI, GO function, and KEGG pathway.
Results indicated FGHP could alleviate CHD syndromes and regulate inflammatory responses in acute myocardial ischemia rats, and the reduction of expression of TNF-α and IL-6 in myocardial tissue would be one of its possible underlying mechanisms.
Our work demonstrated that network pharmacology combined with experimental verification provides a credible method to elucidate the pharmacological mechanism of FGHP against CHD.
American Psychological Association (APA)
Duan, Bailu& Han, Lintao& Ming, Shu-ping& Li, Jingjing& Wang, Qiong& Zhang, Dongning…[et al.]. 2020. Fuling-Guizhi Herb Pair in Coronary Heart Disease: Integrating Network Pharmacology and In Vivo Pharmacological Evaluation. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1154847
Modern Language Association (MLA)
Duan, Bailu…[et al.]. Fuling-Guizhi Herb Pair in Coronary Heart Disease: Integrating Network Pharmacology and In Vivo Pharmacological Evaluation. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1154847
American Medical Association (AMA)
Duan, Bailu& Han, Lintao& Ming, Shu-ping& Li, Jingjing& Wang, Qiong& Zhang, Dongning…[et al.]. Fuling-Guizhi Herb Pair in Coronary Heart Disease: Integrating Network Pharmacology and In Vivo Pharmacological Evaluation. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1154847
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154847