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Renoprotective Effect of Danhong Injection on Streptozotocin-Induced Diabetic Rats through a Peroxisome Proliferator-Activated Receptor γ Mediated Pathway
Joint Authors
Yang, Xue
Xiao, Xiang
Wang, Hailian
Li, Yi
Wang, Li
Li, Guisen
Deng, Shaoping
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The aim of the study was to investigate the protective effect of Danhong injection (DHI) on diabetic kidney disease and explore the potential mechanisms.
Diabetic kidney disease was induced by unilateral nephrectomy, high-fat diet, and streptozotocin.
After DHI administration, the renal function deterioration, 24-hour total urine protein excretion, and elevated serum lipid levels were reversed to some extent, and the renal pathological damage was also ameliorated.
The KEGG pathway enrichment analysis demonstrated that the PPARγ signal pathway was significantly upregulated in DH group.
And the increased expressions of PPARγ and UCP-1 were confirmed by immunohistochemistry, whereas the p38MAPK was significantly decreased.
These data show that DHI could delay the progress of DKD, and the effect might be achieved in part by activating the PPARγ signaling pathway.
American Psychological Association (APA)
Yang, Xue& Xiao, Xiang& Wang, Hailian& Li, Yi& Wang, Li& Li, Guisen…[et al.]. 2018. Renoprotective Effect of Danhong Injection on Streptozotocin-Induced Diabetic Rats through a Peroxisome Proliferator-Activated Receptor γ Mediated Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1154855
Modern Language Association (MLA)
Yang, Xue…[et al.]. Renoprotective Effect of Danhong Injection on Streptozotocin-Induced Diabetic Rats through a Peroxisome Proliferator-Activated Receptor γ Mediated Pathway. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1154855
American Medical Association (AMA)
Yang, Xue& Xiao, Xiang& Wang, Hailian& Li, Yi& Wang, Li& Li, Guisen…[et al.]. Renoprotective Effect of Danhong Injection on Streptozotocin-Induced Diabetic Rats through a Peroxisome Proliferator-Activated Receptor γ Mediated Pathway. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1154855
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154855