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Dracorhodin Perchlorate Accelerates Cutaneous Wound Healing in Wistar Rats
Joint Authors
Jiang, Xiaowen
Qiao, Lu
Liu, Lin
Zhang, Binqing
Yu, Wenhui
Wang, Xue-wei
Han, Yu-wen
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Dracorhodin perchlorate (DP) is extracted from Dragon’s blood, which is widely used in traditional Chinese medicine, especially in wound healing.
The aim of this paper is to investigate the influence of DP ointment, which contained DP dissolved in DMSO and mixed with Vaseline, on cutaneous wound healing in Wistar rats.
Forty Wistar rats were divided into two groups: control and DP groups.
The skin on the back of each rat was punched with two full-thickness wounds and then treated with the corresponding drug.
After 3, 7, 10, 14, and 21 days, four rats were sacrificed for immunological, biochemical, and histological analyses.
Compared with the control treatment, DP could significantly promote wound closure.
Histological and biochemical analyses of the skin biopsies also showed that DP regulated the expression of inflammatory responses by TNF-α and IL-β and by supporting wound tissue growth and collagen deposition.
Western blot revealed that DP could also facilitate the expression of EGF and VEGF proteins.
In conclusion, DP promotes wound healing.
American Psychological Association (APA)
Jiang, Xiaowen& Qiao, Lu& Liu, Lin& Zhang, Binqing& Wang, Xue-wei& Han, Yu-wen…[et al.]. 2017. Dracorhodin Perchlorate Accelerates Cutaneous Wound Healing in Wistar Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1154858
Modern Language Association (MLA)
Jiang, Xiaowen…[et al.]. Dracorhodin Perchlorate Accelerates Cutaneous Wound Healing in Wistar Rats. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1154858
American Medical Association (AMA)
Jiang, Xiaowen& Qiao, Lu& Liu, Lin& Zhang, Binqing& Wang, Xue-wei& Han, Yu-wen…[et al.]. Dracorhodin Perchlorate Accelerates Cutaneous Wound Healing in Wistar Rats. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1154858
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154858