NLRP3 Inflammasome: A Potential Alternative Therapy Target for Atherosclerosis
Joint Authors
Li, Chao
Liu, Yang
Yin, Honglin
Zhang, Xinrong
Li, Yunlun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-31
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Atherosclerosis (AS) is a complex and chronic inflammatory disease that occurs in multiple systems of the human body.
It is an important pathological basis for a variety of diseases and a serious threat to human health.
So far, many theories have been formed to explain the pathogenesis of atherosclerosis, among which “inflammation theory” has gradually become a research focus.
This theory presents that inflammatory response runs through the whole progress of AS, inflammatory cells play as the main executors of AS, and inflammatory mediators are the key molecules of AS.
In the inflammatory process of atherosclerosis, the role of NLRP3 in the atherosclerosis has gradually got the attention of researchers.
NLRP3 is a kind of signal-transductional pattern recognition receptors (PRRs).
After recognizing and binding to the damage factors, NLRP3 inflammasome will be assembled to activate IL-1β and caspase-1 pathways, resulting in promoting the inflammation process of AS, reducing the stability of the plaques, and finally increasing the incidence of adverse cardiovascular events.
Taken above, the article will review the potential benefits of drugs targeting the NLRP3 inflammasome in the therapy of AS.
American Psychological Association (APA)
Liu, Yang& Li, Chao& Yin, Honglin& Zhang, Xinrong& Li, Yunlun. 2020. NLRP3 Inflammasome: A Potential Alternative Therapy Target for Atherosclerosis. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1154871
Modern Language Association (MLA)
Liu, Yang…[et al.]. NLRP3 Inflammasome: A Potential Alternative Therapy Target for Atherosclerosis. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1154871
American Medical Association (AMA)
Liu, Yang& Li, Chao& Yin, Honglin& Zhang, Xinrong& Li, Yunlun. NLRP3 Inflammasome: A Potential Alternative Therapy Target for Atherosclerosis. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1154871
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154871