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Bioaccessibility and Pharmacokinetics of a Commercial Saffron (Crocus sativus L.) Extract
Joint Authors
Almodóvar, Paula
Briskey, David
Rao, Amanda
Prodanov, Marín
Inarejos-García, Antonio M.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
There are few studies about the pharmacokinetics of the low-molecular mass carotenoids crocetin or crocin isomers from saffron (Crocus sativus L.).
None has been performed with a galenic preparation of a standardised saffron extract.
The aim of the present research work was to study the effect of in vitro digestion process on the main bioactive components of saffron extract tablets and the corresponding pharmacokinetic parameters in humans.
Pharmacokinetics were calculated collecting blood samples every 30 min during the first 3 h and at 24 h after administration of two different concentrations (56 and 84 mg of the saffron extract) to 13 healthy human volunteers.
Additionally, an in vitro digestion process was performed in order to determine the bioaccessibility of saffron main bioactive compounds.
Identification and quantification analysis were performed by HPLC-PAD/MS.
Digestion resulted in 40% of bioaccesibility for crocin isomers, whereas, safranal content followed an opposite trend increasing about 2 folds its initial concentration after the digestion process.
Crocetin in plasma was detected in a maximum concentration (Cmax) in blood between 60 and 90 min after oral consumption with dose-dependent response kinetics, showing that crocin isomers from galenic preparation of saffron extract are rapidly transformed into crocetin.
The results showed that this tested galenic form is an efficient way to administer a saffron extract, since the observed crocetin Cmax was similar and more quickly bioavailable than those obtained by other studies with much higher concentrations of crocetin.
American Psychological Association (APA)
Almodóvar, Paula& Briskey, David& Rao, Amanda& Prodanov, Marín& Inarejos-García, Antonio M.. 2020. Bioaccessibility and Pharmacokinetics of a Commercial Saffron (Crocus sativus L.) Extract. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1154883
Modern Language Association (MLA)
Almodóvar, Paula…[et al.]. Bioaccessibility and Pharmacokinetics of a Commercial Saffron (Crocus sativus L.) Extract. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1154883
American Medical Association (AMA)
Almodóvar, Paula& Briskey, David& Rao, Amanda& Prodanov, Marín& Inarejos-García, Antonio M.. Bioaccessibility and Pharmacokinetics of a Commercial Saffron (Crocus sativus L.) Extract. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1154883
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154883