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Plant-Derived Products for Treatment of Vascular Intima Hyperplasia Selectively Inhibit Vascular Smooth Muscle Cell Functions
Joint Authors
Al-ani, Mohanad Kh
Pan, Xin
Xu, Kang
Chi, Qingjia
Dong, Nianguo
Qiu, Xuefeng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-11
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Natural products are used widely for preventing intimal hyperplasia (IH), a common cardiovascular disease.
Four different cells initiate and progress IH, namely, vascular smooth muscle, adventitial and endothelial cells, and circulation or bone marrow-derived cells.
Vascular smooth muscle cells (VSMCs) play a critical role in initiation and development of intimal thickening and formation of neointimal hyperplasia.
In this review, we describe the different originating cells involved in vascular IH and emphasize the effect of different natural products on inhibiting abnormal cellular functions, such as VSMC proliferation and migration.
We further present a classification for the different natural products like phenols, flavonoids, terpenes, and alkaloids that suppress VSMC growth.
Abnormal VSMC physiology involves disturbance in MAPKs, PI3K/AKT, JAK-STAT, FAK, and NF-κB signal pathways.
Most of the natural isolate studies have revealed G1/S phase of cell cycle arrest, decreased ROS production, induced cell apoptosis, restrained migration, and downregulated collagen deposition.
It is necessary to screen optimal drugs from natural sources that preferentially inhibit VSMC rather than vascular endothelial cell growth to prevent early IH, restenosis following graft implantation, and atherosclerotic diseases.
American Psychological Association (APA)
Xu, Kang& Al-ani, Mohanad Kh& Pan, Xin& Chi, Qingjia& Dong, Nianguo& Qiu, Xuefeng. 2018. Plant-Derived Products for Treatment of Vascular Intima Hyperplasia Selectively Inhibit Vascular Smooth Muscle Cell Functions. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1154888
Modern Language Association (MLA)
Xu, Kang…[et al.]. Plant-Derived Products for Treatment of Vascular Intima Hyperplasia Selectively Inhibit Vascular Smooth Muscle Cell Functions. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-17.
https://search.emarefa.net/detail/BIM-1154888
American Medical Association (AMA)
Xu, Kang& Al-ani, Mohanad Kh& Pan, Xin& Chi, Qingjia& Dong, Nianguo& Qiu, Xuefeng. Plant-Derived Products for Treatment of Vascular Intima Hyperplasia Selectively Inhibit Vascular Smooth Muscle Cell Functions. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1154888
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154888