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Myristica lowiana Phytochemicals as Inhibitor of Plasmid Conjugation in Escherichia coli
Joint Authors
Kwapong, Awo Afi
Soares, Sarah
Teo, Stephen Ping
Stapleton, Paul
Gibbons, Simon
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-19
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Hexane extract and methanol fraction from the stem bark of Myristica lowiana specifically and significantly inhibited the conjugal transfer of the IncW plasmid R7K, a plasmid which harbors ampicillin-, streptomycin-, and spectinomycin-resistant genes.
The transfer of this plasmid via the conjugative pilli of Escherichia coli was reduced by 76.5 ± 2.0% and 79.0 ± 1.2% by hexane extract and methanol fraction of M.
lowiana, respectively.
The hexane extract exhibited significant anti-conjugant activity at a non-cytotoxic concentration of 100 mg/L as assessed against adult human dermal fibroblast cells.
The hexane extract and methanol fraction were screened using phytochemical tests, NMR spectroscopy, IR spectroscopy, and high-resolution electrospray ionization mass spectrometry (HRESIMS) and were found to contain terpenoids, sterols, and fatty acids.
American Psychological Association (APA)
Kwapong, Awo Afi& Soares, Sarah& Teo, Stephen Ping& Stapleton, Paul& Gibbons, Simon. 2020. Myristica lowiana Phytochemicals as Inhibitor of Plasmid Conjugation in Escherichia coli. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1154895
Modern Language Association (MLA)
Kwapong, Awo Afi…[et al.]. Myristica lowiana Phytochemicals as Inhibitor of Plasmid Conjugation in Escherichia coli. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1154895
American Medical Association (AMA)
Kwapong, Awo Afi& Soares, Sarah& Teo, Stephen Ping& Stapleton, Paul& Gibbons, Simon. Myristica lowiana Phytochemicals as Inhibitor of Plasmid Conjugation in Escherichia coli. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1154895
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154895