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Morinda Officinalis Polysaccharides Stimulate Hypothalamic GnRH Secretion in Varicocele Progression
Joint Authors
Wang, Wei
Zhao, Xiaozhen
Wang, Feng
Zhu, Zhu
Huang, Feng
Zhang, Yonghong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-20
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Varicoceles (VCs) are the predominant cause of male infertility and are a risk factor for chronic venous disease.
Morinda officinalis (M.
officinalis) is a traditional Chinese medicine used to tonify the kidney and strengthen yang.
In this study, we evaluated the effects of water-soluble polysaccharides extracted from M.
officinalis (MOPs) on gonadotropin-release hormone (GnRH) secretion in a classic experimental left VC (ELV) rat model.
Intragastric administration of MOPs at a dose ranging from 50 mg kg−1 to 100 mg kg−1 facilitated improvements in sperm parameters and seminiferous epithelial structures, modulated serum hormone profiles, and stimulated GnRH synthesis and release in the hypothalamus.
MOPs also promoted spinogenesis and functional spine maturation in the arcuate nuclei (Arc), wherein they acted mainly on Kiss1 and GnRH neurons.
Moreover, MOP-mediated Kisspeptin-GPR54 pathway upregulation and MAPK phosphorylation activation may have been responsible for increases in GnRH synthesis and release.
Collectively, the findings of this study indicate that MOPs were effective in stimulating GnRH secretion, possibly by upregulating the Kiss1/GPR54 pathway and enhancing synaptic plasticity, and that MOPs can serve as a therapy for early VCs.
American Psychological Association (APA)
Zhu, Zhu& Huang, Feng& Wang, Feng& Zhang, Yonghong& Zhao, Xiaozhen& Wang, Wei. 2017. Morinda Officinalis Polysaccharides Stimulate Hypothalamic GnRH Secretion in Varicocele Progression. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1154896
Modern Language Association (MLA)
Zhu, Zhu…[et al.]. Morinda Officinalis Polysaccharides Stimulate Hypothalamic GnRH Secretion in Varicocele Progression. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1154896
American Medical Association (AMA)
Zhu, Zhu& Huang, Feng& Wang, Feng& Zhang, Yonghong& Zhao, Xiaozhen& Wang, Wei. Morinda Officinalis Polysaccharides Stimulate Hypothalamic GnRH Secretion in Varicocele Progression. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1154896
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154896