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Trigonella foenum-graecum L. Sprouted Seed Extract: Its Chemical HPLC Analysis, Abortive Effect, and Neurodevelopmental Toxicity on Mice
Joint Authors
El Gabbas, Zineb
Bezza, Kenza
Laadraoui, Jawad
Ait Laaradia, Mehdi
Oufquir, Sara
Aboufatima, Rachida
Chait, Abderrahman
Sokar, Zahra
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The Trigonella foenum-graecum L.
seeds, in a dormant or sprouted state, have been largely investigated for their therapeutic activities such as being antidiabetic, antioxidant, cholesterol-lowering, and as a digestive enhancer too.
Nevertheless, there are no studies evaluating the potential developmental toxicity of germinated grains despite the availability of numerous research studies demonstrating the teratogenicity effect of unsprouted seeds.
Therefore, this research work was conducted to assess the impact of fenugreek sprouts on maternal and neurobehavioral developmental toxicities on mice.
The lyophilized aqueous extract of germinated seeds was administered via oral gavage on a daily basis to five groups of mated female mice throughout pregnancy at doses of 200, 500, 800, and 1000 mg/kg/day and the control group was administered distilled water.
Maternal reproductive toxicity was evaluated, and the surviving pups were assessed for their physical development, malformation, and neurobehavioral toxicity by using a battery of tests from birth to the 25th postnatal day.
Additionally, the aqueous extract of germinated and ungerminated seeds was analyzed by high-performance liquid chromatography (HPLC) for a comparison of their major compounds.
For pregnant treated female mice, no death and no intoxication symptoms have been registered during the test.
However, the sprouts’ extract has provoked a significant decrease in fertility, spontaneous abortion, pup’s mortality, and neurobehavioral disorder in offspring.
HPLC analysis reveals an increase in total phenolic compound concentration by the process of sprouting.
American Psychological Association (APA)
Oufquir, Sara& Ait Laaradia, Mehdi& El Gabbas, Zineb& Bezza, Kenza& Laadraoui, Jawad& Aboufatima, Rachida…[et al.]. 2020. Trigonella foenum-graecum L. Sprouted Seed Extract: Its Chemical HPLC Analysis, Abortive Effect, and Neurodevelopmental Toxicity on Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1154898
Modern Language Association (MLA)
Oufquir, Sara…[et al.]. Trigonella foenum-graecum L. Sprouted Seed Extract: Its Chemical HPLC Analysis, Abortive Effect, and Neurodevelopmental Toxicity on Mice. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1154898
American Medical Association (AMA)
Oufquir, Sara& Ait Laaradia, Mehdi& El Gabbas, Zineb& Bezza, Kenza& Laadraoui, Jawad& Aboufatima, Rachida…[et al.]. Trigonella foenum-graecum L. Sprouted Seed Extract: Its Chemical HPLC Analysis, Abortive Effect, and Neurodevelopmental Toxicity on Mice. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1154898
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154898