N-Butanol and Aqueous Fractions of Red Maca Methanolic Extract Exerts Opposite Effects on Androgen and Oestrogens Receptors (Alpha and Beta) in Rats with Testosterone-Induced Benign Prostatic Hyperplasia
Joint Authors
Orihuela, Pedro
Gonzales, Gustavo F.
Fano, Diego
Vásquez-Velásquez, Cinthya
Gonzales-Castañeda, Cynthia
Guajardo-Correa, Emanuel
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Benign Prostatic Hyperplasia (BPH) affects, worldwide, 50% of 60-year-old men.
The Peruvian plant red maca (Lepidium meyenii) inhibits BPH in rodents.
This study aimed to determine the effects of methanolic red maca extract and its n-butanol and aqueous fractions on expression of androgen and oestrogen receptors in rats with testosterone enanthate-induced BPH.
Thirty-six rats in six groups were studied.
Control group received 2 mL of vehicle orally and 0.1 mL of propylene glycol intramuscularly.
The second group received vehicle orally and testosterone enanthate (TE) (25 mg/0.1 mL) intramuscularly in days 1 and 7.
The other four groups were BPH-induced with TE and received, during 21 days, 3.78 mg/mL of finasteride, 18.3 mg/mL methanol extract of red maca, 2 mg/mL of n-butanol fraction, or 16.3 mg/mL of aqueous fraction from red maca.
Treatments with red maca extract and its n-butanol but not aqueous fraction reduced prostate weight similar to finasteride.
All maca treated groups restored the expression of ERβ, but only the aqueous fraction increased androgen receptors and ERα.
In conclusion, butanol fraction of red maca reduced prostate size in BPH by restoring expression of ERβ without affecting androgen receptors and ERα.
This effect was not observed with aqueous fraction of methanolic extract of red maca.
American Psychological Association (APA)
Fano, Diego& Vásquez-Velásquez, Cinthya& Gonzales-Castañeda, Cynthia& Guajardo-Correa, Emanuel& Orihuela, Pedro& Gonzales, Gustavo F.. 2017. N-Butanol and Aqueous Fractions of Red Maca Methanolic Extract Exerts Opposite Effects on Androgen and Oestrogens Receptors (Alpha and Beta) in Rats with Testosterone-Induced Benign Prostatic Hyperplasia. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1154915
Modern Language Association (MLA)
Fano, Diego…[et al.]. N-Butanol and Aqueous Fractions of Red Maca Methanolic Extract Exerts Opposite Effects on Androgen and Oestrogens Receptors (Alpha and Beta) in Rats with Testosterone-Induced Benign Prostatic Hyperplasia. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1154915
American Medical Association (AMA)
Fano, Diego& Vásquez-Velásquez, Cinthya& Gonzales-Castañeda, Cynthia& Guajardo-Correa, Emanuel& Orihuela, Pedro& Gonzales, Gustavo F.. N-Butanol and Aqueous Fractions of Red Maca Methanolic Extract Exerts Opposite Effects on Androgen and Oestrogens Receptors (Alpha and Beta) in Rats with Testosterone-Induced Benign Prostatic Hyperplasia. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1154915
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154915