Tripterygium wilfordii Glycosides Upregulate the New Anti-Inflammatory Cytokine IL-37 through ERK12 and p38 MAPK Signal Pathways
Joint Authors
Wang, Sen
Li, Rumeng
He, Suhui
He, Lingge
Zhao, Hang
Deng, Xiaohong
Chen, Zhangquan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
As a Chinese traditional patent medicine, Tripterygium wilfordii glycosides (TWG) have been approved by the China State Food and Drug Administration (Z32021007) for autoimmune and inflammatory diseases.
Application of TWG leads to significant decrease of the inflammatory cytokines, such as IL-6, IL-1β, and TNF-α.
However, little is known whether TWG could regulate the anti-inflammatory cytokines and what the mechanism is.
Here, we found that TWG could induce the upregulation of IL-37 which is a new anti-inflammatory cytokine.
Furthermore, the inhibitors of ERK1/2 and/or p38 MAPK pathways suppressed IL-37 expression induced by TWG, indicating that the two pathways took part in this process.
In conclusion, TWG could upregulate the anti-inflammatory cytokine IL-37 and ERK1/2 and p38 MAPK signal pathways were involved in the upregulation of IL-37 induced by TWG.
The results showed that TWG had a potent activity on promoting the expression of IL-37, a new anti-inflammatory cytokine, which help further understanding the anti-inflammatory mechanism for the clinical application of TWG in therapy of diseases.
American Psychological Association (APA)
Wang, Sen& Li, Rumeng& He, Suhui& He, Lingge& Zhao, Hang& Deng, Xiaohong…[et al.]. 2017. Tripterygium wilfordii Glycosides Upregulate the New Anti-Inflammatory Cytokine IL-37 through ERK12 and p38 MAPK Signal Pathways. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1154927
Modern Language Association (MLA)
Wang, Sen…[et al.]. Tripterygium wilfordii Glycosides Upregulate the New Anti-Inflammatory Cytokine IL-37 through ERK12 and p38 MAPK Signal Pathways. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1154927
American Medical Association (AMA)
Wang, Sen& Li, Rumeng& He, Suhui& He, Lingge& Zhao, Hang& Deng, Xiaohong…[et al.]. Tripterygium wilfordii Glycosides Upregulate the New Anti-Inflammatory Cytokine IL-37 through ERK12 and p38 MAPK Signal Pathways. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1154927
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154927