Antiobesity and Anti-Inflammatory Effects of Orally Administered Bonito Extracts on Mice Fed a High-Fat Diet
Joint Authors
Matsumoto, Takashi
Fife-Koshinomi, Nichole
Iha, Hidekatsu
Ikebe, Emi
Yahiro, Takaaki
Ikebe, Taichi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-24
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Background.
The condensed fermentative extract of bonito (BoE), skipjack tuna (Katsuwonus pelamis), has claimed its health conditioning effects against lifestyle-related diseases such as hypertension and type 2 diabetes.
Methods.
We evaluated the antiobesity and anti-inflammatory effects of BoE on mice fed a high-fat diet (HFD).
Mice (9 weeks of age) were maintained for 11 weeks on HFD with or without BoE (50 mg or 500 mg/kg).
Results.
Compared with untreated mice, BoE50 or BoE500 mice achieved maximum weight reductions of 7.4% (males) and 11.4% (females), and visceral fat in male BoE500 mice was more decreased among all mice (P = 0.00459).
Furthermore, an antiobesity gene uncoupling protein-1 was significantly induced in the visceral fat tissues of male BoE500 (P = 0.0110) and female BoE50 and BoE500 mice (P = 0.0110 and P = 0.0110, resp.).
Finally, we detected reduced amount of granulocyte-colony stimulating factor (P = 0.0250) in the sera of female BoE50 and interleukin- (IL-) 5 (P = 0.0120), IL-6 (P = 0.0118), and IL-13 (P = 0.0243) in female BoE500 mice.
Conclusion.
The antiobesity and anti-inflammatory effects of BoE were demonstrated with our examination system and any toxic adverse effects were not observed in mice during the 3-month investigation.
American Psychological Association (APA)
Ikebe, Emi& Fife-Koshinomi, Nichole& Matsumoto, Takashi& Yahiro, Takaaki& Ikebe, Taichi& Iha, Hidekatsu. 2017. Antiobesity and Anti-Inflammatory Effects of Orally Administered Bonito Extracts on Mice Fed a High-Fat Diet. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1154936
Modern Language Association (MLA)
Ikebe, Emi…[et al.]. Antiobesity and Anti-Inflammatory Effects of Orally Administered Bonito Extracts on Mice Fed a High-Fat Diet. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1154936
American Medical Association (AMA)
Ikebe, Emi& Fife-Koshinomi, Nichole& Matsumoto, Takashi& Yahiro, Takaaki& Ikebe, Taichi& Iha, Hidekatsu. Antiobesity and Anti-Inflammatory Effects of Orally Administered Bonito Extracts on Mice Fed a High-Fat Diet. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1154936
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154936