Combined Donepezil and Ethanolic Extract of Propolis Improved Memory Better Than Donepezil and Propolis Monotherapy in Wild Type Drosophila melanogaster
Joint Authors
Semuyaba, Ibrahim
Safiriyu, Abass Alao
Ayikobua, Emmanuel Tiyo
Eze, Daniel Ejike
Kalange, Muhamudu
Nansunga, Mariam
Okpanachi, Alfred Omachonu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-12
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Donepezil is the most common drug used in the treatment of disorders associated with memory loss, especially that in Alzheimer’s disease.
Healthy individuals however have continued to use it as a memory enhancer.
This study was aimed at evaluating the combined therapy of donepezil and propolis on cognition in Drosophila melanogaster.
Method.
Drosophila melanogaster flies were divided into five groups and fed with the different treatment doses of ethanolic extract of propolis and donepezil as follows: normal food, propolis 250 mg/mL, propolis 50 mg/mL, donepezil 0.001M, and donepezil 0.001M/propolis 50 mg/mL added to their food.
The flies were fed from larval stage for 30 days.
The memory and learning tests were conducted after every 10 days to assess improvement with time.
Results.
The results obtained showed that the combination of propolis with donepezil caused a remarkable improvement in both the short- and long-term memory.
In addition, there was a dose dependent improvement with the administration of propolis.
Conclusion.
Propolis extract obtained from different parts of Uganda expressed cognitive improvement when coadministered with donepezil in wild type Drosophila melanogaster.
American Psychological Association (APA)
Ayikobua, Emmanuel Tiyo& Semuyaba, Ibrahim& Eze, Daniel Ejike& Kalange, Muhamudu& Nansunga, Mariam& Okpanachi, Alfred Omachonu…[et al.]. 2018. Combined Donepezil and Ethanolic Extract of Propolis Improved Memory Better Than Donepezil and Propolis Monotherapy in Wild Type Drosophila melanogaster. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1154954
Modern Language Association (MLA)
Ayikobua, Emmanuel Tiyo…[et al.]. Combined Donepezil and Ethanolic Extract of Propolis Improved Memory Better Than Donepezil and Propolis Monotherapy in Wild Type Drosophila melanogaster. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1154954
American Medical Association (AMA)
Ayikobua, Emmanuel Tiyo& Semuyaba, Ibrahim& Eze, Daniel Ejike& Kalange, Muhamudu& Nansunga, Mariam& Okpanachi, Alfred Omachonu…[et al.]. Combined Donepezil and Ethanolic Extract of Propolis Improved Memory Better Than Donepezil and Propolis Monotherapy in Wild Type Drosophila melanogaster. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1154954
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154954