A Meta-Analysis of the Efficacy of Prokinetic Agents against Glycemic Control
Joint Authors
Kim, Yeon-Ji
Lee, Seung Jae
Chung, Woo Chul
Source
Gastroenterology Research and Practice
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Prokinetic agents are used in diabetic gastroparesis patients to improve gastric emptying and upper gastrointestinal (GI) symptoms.
However, the efficacy of prokinetic agents against glycemic control is questionable.
Therefore, we conducted a systemic review and meta-analysis to determine the efficacy of prokinetic agents against glycemic control.
Methods.
Randomized controlled trials (RCTs) evaluating the effect of prokinetics were identified by searching PubMed, Embase, and the Cochrane Library databases until April 2018.
The primary outcome was changes in the mean value of glycosylated hemoglobin (HbA1c), fasting blood sugar (FBS), and fasting serum insulin (FINS).
The pooled standardized mean differences (SMD) with 95% confidence intervals (CIs) were calculated by evaluating the strength of the association.
We used the random effect models to analyze these markers.
The effects of each component of the prokinetic agents on glycemic control were separately analyzed.
Results.
Five RCTs with 190 patients met the criteria and were included in the meta-analysis.
There were statistically significant SMD between prokinetics and placebo-controlled groups with respect to the reduction of HbA1c (-1.141, 95% CI -1.843, -0.438; P<0.01).
No statistically significant differences were noted between the two groups for FBS (-1.270, 95% CI -2.613, -0.074; P=0.06) and FINS (0.359, 95% CI -1.205~1.923; P=0.65).
Conclusions.
Prokinetics have a positive effect on glycemic control.
Further large-scale prospective studies are needed.
American Psychological Association (APA)
Kim, Yeon-Ji& Chung, Woo Chul& Lee, Seung Jae. 2019. A Meta-Analysis of the Efficacy of Prokinetic Agents against Glycemic Control. Gastroenterology Research and Practice،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1154982
Modern Language Association (MLA)
Kim, Yeon-Ji…[et al.]. A Meta-Analysis of the Efficacy of Prokinetic Agents against Glycemic Control. Gastroenterology Research and Practice No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1154982
American Medical Association (AMA)
Kim, Yeon-Ji& Chung, Woo Chul& Lee, Seung Jae. A Meta-Analysis of the Efficacy of Prokinetic Agents against Glycemic Control. Gastroenterology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1154982
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154982