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Calponin 3 Regulates Cell Invasion and Doxorubicin Resistance in Gastric Cancer
Joint Authors
Hong, Keun-Seok
Kim, Hyemin
Kim, Seon-Hee
Kim, Minju
Yoo, Jiyun
Source
Gastroenterology Research and Practice
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Calponin 3 (CNN3) is an F-actin-binding protein that regulates actin cytoskeletal rearrangement.
However, the role of CNN3 in cancer cell invasion and resistance to chemotherapeutic agents has not yet been investigated.
The present study was undertaken to investigate whether CNN3 influences cancer-related phenotypes in gastric cancer.
We demonstrate that CNN3 contributes to cell invasion and resistance to doxorubicin in gastric cancer.
CNN3 expression was markedly elevated in highly invasive cancer cell lines compared to less invasive or noninvasive cancer cell lines.
Depletion of CNN3 protein suppressed the invasive ability of gastric cancer cells.
The highly invasive MKN-28 gastric cancer cells were more resistant to doxorubicin than the noninvasive MKN-45 cells; however, knockdown of CNN3 expression in MKN-28 cells resensitized them to doxorubicin treatment.
Taken together, our results suggest that CNN3 plays a key role in invasiveness and doxorubicin resistance in gastric cancer cells.
American Psychological Association (APA)
Hong, Keun-Seok& Kim, Hyemin& Kim, Seon-Hee& Kim, Minju& Yoo, Jiyun. 2019. Calponin 3 Regulates Cell Invasion and Doxorubicin Resistance in Gastric Cancer. Gastroenterology Research and Practice،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1154990
Modern Language Association (MLA)
Hong, Keun-Seok…[et al.]. Calponin 3 Regulates Cell Invasion and Doxorubicin Resistance in Gastric Cancer. Gastroenterology Research and Practice No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1154990
American Medical Association (AMA)
Hong, Keun-Seok& Kim, Hyemin& Kim, Seon-Hee& Kim, Minju& Yoo, Jiyun. Calponin 3 Regulates Cell Invasion and Doxorubicin Resistance in Gastric Cancer. Gastroenterology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1154990
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154990