Clinical Effects and Safety of Zhi Sou San for Cough: A Meta-Analysis of Randomized Trials
Joint Authors
Ding, Pinpin
Zhu, Jia
Cheng, Ningchang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Introduction.
Zhi Sou San (ZSS), a traditional Chinese prescription, has been widely applied in treating cough.
The purpose of this meta-analysis was to evaluate the effectiveness and safety of ZSS for cough.
Methods.
We searched relevant articles up to 5 March 2017 in seven electronic databases: the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, PubMed, Chinese National Knowledge Infrastructure (CNKI), Cqvip Database (VIP), China Biology Medicine disc (CBM), and Wanfang Data.
Randomized controlled trials (RCTs) were eligible, regardless of blinding.
The primary outcome was the total effective rate.
Results.
Forty-six RCTs with a total of 4007 participants were identified.
Compared with western medicine, ZSS significantly improved the total effective rate (OR: 4.45; 95% CI: 3.62–5.47) and the pulmonary function in terms of FEV1 (OR: 0.35; 95% CI: 0.24–0.46) and decreased the adverse reactions (OR: 0.05; 95% CI: 0.02–0.01) and the recurrence rate (OR: 0.30; 95% CI: 0.16–0.57).
However, there was no significant improvement in the cough symptom score comparing ZSS with western medicine.
Conclusions.
This meta-analysis shows that ZSS has significant additional benefits and relative safety in treating cough.
However, more rigorously designed investigations and studies, with large sample sizes, are needed because of the methodological flaws and low quality of the included trials in this meta-analysis.
American Psychological Association (APA)
Cheng, Ningchang& Zhu, Jia& Ding, Pinpin. 2017. Clinical Effects and Safety of Zhi Sou San for Cough: A Meta-Analysis of Randomized Trials. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1155000
Modern Language Association (MLA)
Cheng, Ningchang…[et al.]. Clinical Effects and Safety of Zhi Sou San for Cough: A Meta-Analysis of Randomized Trials. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1155000
American Medical Association (AMA)
Cheng, Ningchang& Zhu, Jia& Ding, Pinpin. Clinical Effects and Safety of Zhi Sou San for Cough: A Meta-Analysis of Randomized Trials. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1155000
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155000