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Biological and Phytochemical Investigations on Caesalpinia benthamiana, a Plant Traditionally Used as Antimalarial in Guinea
Joint Authors
Maes, Louis
Loua, Jean
Traore, Mohamed Sahar
Camara, Aissata
Balde, Mamadou Aliou
Pieters, Luc
Balde, Aliou Mamadou
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Caesalpinia benthamiana is widely used as antimalarial in Guinean traditional medicine.
Leaf extracts of the plant were tested for their in vitro antiprotozoal activity against Trypanosoma brucei brucei and T.
cruzi and the chloroquine-sensitive Ghana strain of Plasmodium falciparum along with their cytotoxicity on MRC-5 cells.
The methanolic extract showed the strongest antiprotozoal activity against P.
falciparum (IC50 4 μg/ml), a good activity against T.
brucei (IC50 13 μg/ml), and a moderate activity against T.
cruzi (IC50 31 μg/ml) along with an IC50 on human MRC-5 cells of 32 μg/ml.
Bioassay-guided fractionation from the methanolic extract led to antiplasmodially active subfractions.
A prospective, placebo-controlled ethnotherapeutic trial assessed the antimalarial effectiveness and tolerability of C.
benthamiana syrup administered orally to children with uncomplicated malaria as compared with chloroquine syrup.
Phytochemical screening of the leaf extracts indicated the presence of flavonoids, terpenoids, tannins, saponins, and iridoids.
American Psychological Association (APA)
Loua, Jean& Traore, Mohamed Sahar& Camara, Aissata& Balde, Mamadou Aliou& Maes, Louis& Pieters, Luc…[et al.]. 2017. Biological and Phytochemical Investigations on Caesalpinia benthamiana, a Plant Traditionally Used as Antimalarial in Guinea. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1155001
Modern Language Association (MLA)
Loua, Jean…[et al.]. Biological and Phytochemical Investigations on Caesalpinia benthamiana, a Plant Traditionally Used as Antimalarial in Guinea. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1155001
American Medical Association (AMA)
Loua, Jean& Traore, Mohamed Sahar& Camara, Aissata& Balde, Mamadou Aliou& Maes, Louis& Pieters, Luc…[et al.]. Biological and Phytochemical Investigations on Caesalpinia benthamiana, a Plant Traditionally Used as Antimalarial in Guinea. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1155001
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155001